Genetics of inflammation in the gastrointestinal tract and how it can cause cancer

Mairi H. McLean, Emad M. El-Omar (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

20 Citations (Scopus)

Abstract

Genetic epidemiology is an important discipline that is helping to unravel the aetiology and pathogenesis of complex human diseases. In the context of gastrointestinal malignancy, the paradigm model of host genetic influence on disease outcome is H. pylori-associated gastric adenocarcinoma. This cancer represents a classic example of an inflammation-induced malignancy and highlights the importance of host genetics in disease development. This chapter gives an insight into how genetic epidemiology can play an important role in the development of gastric cancer. Increasing our understanding of host genetics in cancer development may allow particularly susceptible individuals to be targeted for screening or treatment to reduce risk of future malignant transformation.

Original languageEnglish
Title of host publicationInflammation and Gastrointestinal Cancers
EditorsJanusz A. Z. Jankowski
Place of PublicationBerlin
PublisherSpringer Verlag
Pages173-183
Number of pages11
Volume185
ISBN (Electronic)9783642035036
ISBN (Print)9783642035029
DOIs
Publication statusPublished - 2011

Publication series

NameRecent Results in Cancer Research
ISSN (Print)0080-0015

Keywords

  • Gastric Cancer
  • Pylorus Infection
  • Gastric Cancer Risk
  • Gastric Atrophy
  • Prostate Stem Cell Antigen

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  • Cite this

    McLean, M. H., & El-Omar, E. M. (2011). Genetics of inflammation in the gastrointestinal tract and how it can cause cancer. In J. A. Z. Jankowski (Ed.), Inflammation and Gastrointestinal Cancers (Vol. 185, pp. 173-183). (Recent Results in Cancer Research). Springer Verlag. https://doi.org/10.1007/978-3-642-03503-6_11