Genetics of renal tumours

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    The two main renal tumours, Wilms' tumour and renal cell carcinoma, are associated with distinct molecular genetic abnormalities. The genes involved behave as Knudson oncosuppressor genes. Further dissection of the molecular biology pathways involving WT1 and VHL genes is providing fascinating insight into the biology of these genes, the development and cell biology of the kidney and its tumours.
    Original languageEnglish
    Pages (from-to)127-40
    Number of pages14
    JournalCancer and Metastasis Reviews
    Volume16
    Issue number1-2
    DOIs
    Publication statusPublished - 1997

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