Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Alexander Doney, Ify Mordi, Colin N. Palmer, Helen Parry, Abirami Veluchamy, Chim C. Lang

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Abstract

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.

Original languageEnglish
Article number163
Pages (from-to)1-12
Number of pages12
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 9 Jan 2020

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Mendelian Randomization Analysis
pathogenesis
genome
Heart Failure
Genes
Genome
coronary artery disease
fibrillation
Genome-Wide Association Study
loci
Atrial Fibrillation
Coronary Artery Disease
functional analysis
etiology
hypertension
homeostasis
Functional analysis
mortality
Cell Aging
arteries

Cite this

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abstract = "Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.",
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. / Doney, Alexander; Mordi, Ify; Palmer, Colin N.; Parry, Helen; Veluchamy, Abirami; Lang, Chim C.

In: Nature Communications, Vol. 11, No. 1, 163, 09.01.2020, p. 1-12.

Research output: Contribution to journalArticle

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