Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Celine Bellenguez, Steve Bevan, Andreas Gschwendtner, Chris C. A. Spencer, Annette I. Burgess, Matti Pirinen, Caroline A. Jackson, Matthew Traylor, Amy Strange, Zhan Su, Gavin Band, Paul D. Syme, Rainer Malik, Joanna Pera, Bo Norrving, Robin Lemmens, Colin Freeman, Renata Schanz, Tom James, Deborah PooleLee Murphy, Helen Segal, Lynelle Cortellini, Yu-Ching Cheng, Daniel Woo, Michael A. Nalls, Bertram Müller-Myhsok, Christa Meisinger, Udo Seedorf, Helen Ross-Adams, Steven Boonen, Dorota Wloch-Kopec, Valerie Valant, Julia Slark, Karen Furie, Hossein Delavaran, Cordelia Langford, Panos Deloukas, Sarah Edkins, Sarah Hunt, Emma Gray, Serge Dronov, Leena Peltonen, Solveig Gretarsdottir, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Giorgio B. Boncoraglio, Eugenio A. Parati, Colin N. A. Palmer, WTCCC2, ISGC

    Research output: Contribution to journalArticlepeer-review

    296 Citations (Scopus)

    Abstract

    Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.

    Original languageEnglish
    Pages (from-to)328-U141
    Number of pages8
    JournalNature Genetics
    Volume44
    Issue number3
    DOIs
    Publication statusPublished - Mar 2012

    Fingerprint

    Dive into the research topics of 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke'. Together they form a unique fingerprint.

    Cite this