Genome-wide association study of receptive language ability of 12-year-olds

Nicole Harlaar (Lead / Corresponding author), Emma L. Meaburn (Lead / Corresponding author), Marianna E. Hayiou-Thomas, Oliver S. P. Davis, Sophia Docherty, Ken B. Hanscombe, Claire M. A. Haworth, Thomas S. Price, Maciej Trzaskowski, Philip S. Dale, Robert Plomin, Wellcome Trust Case Control Consortium

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    Abstract

    PURPOSE: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach.

    METHOD: The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores.

    RESULTS: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10 -8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds.

    CONCLUSIONS: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.

    Original languageEnglish
    Pages (from-to)96-105
    Number of pages10
    JournalJournal of Speech, Language, and Hearing Research
    Volume57
    Issue number1
    DOIs
    Publication statusPublished - Feb 2014

    Keywords

    • Child
    • Child Language
    • Female
    • Genome-Wide Association Study
    • Genotype
    • Humans
    • Language Development
    • Language Development Disorders
    • Longitudinal Studies
    • Phenotype
    • Polymorphism, Single Nucleotide
    • Semantics
    • Vocabulary

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  • Cite this

    Harlaar, N., Meaburn, E. L., Hayiou-Thomas, M. E., Davis, O. S. P., Docherty, S., Hanscombe, K. B., Haworth, C. M. A., Price, T. S., Trzaskowski, M., Dale, P. S., Plomin, R., & Wellcome Trust Case Control Consortium (2014). Genome-wide association study of receptive language ability of 12-year-olds. Journal of Speech, Language, and Hearing Research, 57(1), 96-105. https://doi.org/10.1044/1092-4388(2013/12-0303)