Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley

Martin Mascher, Verena J. Schuenemann, Uri Davidovich, Nimrod Marom, Axel Himmelbach, Sariel Hübner, Abraham Korol, Michal David, Ella Reiter, Simone Riehl, Mona Schreiber, Samuel H. Vohr, Richard E. Green, Ian K. Dawson, Joanne Russell, Benjamin Kilian, Gary J. Muehlbauer, Robert Waugh, Tzion Fahima (Lead / Corresponding author), Johannes Krause (Lead / Corresponding author)Ehud Weiss, Nils Stein

Research output: Contribution to journalLetter

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Abstract

The cereal grass barley was domesticated about 10,000 years ago in the Fertile Crescent and became a founder crop of Neolithic agriculture. Here, we report genome sequences of five 6,000-year-old barley grains excavated at a cave in the Judean Desert close to the Dead Sea. Comparison to whole exome sequence data from a diversity panel of present-day barley accessions revealed the close affinity of ancient samples to extant landraces from the Southern Levant and Egypt, consistent with a proposed origin of domesticated barley in the Upper Jordan Valley. Our findings suggest that barley landraces grown in present-day Israel in the past six millennia have not experienced a major lineage turnover although there is evidence for gene flow between cultivated and sympatric wild populations. We show the utility of ancient genomes from desiccated archaeobotanical remains in informing research into the origin, early domestication and subsequent migration of crop species.
Original languageEnglish
Pages (from-to)1089-1093
Number of pages5
JournalNature Genetics
Volume48
Issue number9
Early online date18 Jul 2016
DOIs
Publication statusPublished - Sep 2016

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Hordeum
Genome
Exome
Jordan
Gene Flow
Egypt
Israel
Poaceae
Agriculture
Domestication
Research
Population

Keywords

  • Genomics
  • Plant genetics

Cite this

Mascher, M., J. Schuenemann, V., Davidovich, U., Marom, N., Himmelbach, A., Hübner, S., ... Stein, N. (2016). Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley. Nature Genetics, 48(9), 1089-1093. https://doi.org/10.1038/ng.3611
Mascher, Martin ; J. Schuenemann, Verena ; Davidovich, Uri ; Marom, Nimrod ; Himmelbach, Axel ; Hübner, Sariel ; Korol, Abraham ; David, Michal ; Reiter, Ella ; Riehl, Simone ; Schreiber, Mona ; Vohr, Samuel H. ; Green, Richard E. ; Dawson, Ian K. ; Russell, Joanne ; Kilian, Benjamin ; Muehlbauer, Gary J. ; Waugh, Robert ; Fahima, Tzion ; Krause, Johannes ; Weiss, Ehud ; Stein, Nils. / Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley. In: Nature Genetics. 2016 ; Vol. 48, No. 9. pp. 1089-1093.
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abstract = "The cereal grass barley was domesticated about 10,000 years ago in the Fertile Crescent and became a founder crop of Neolithic agriculture. Here, we report genome sequences of five 6,000-year-old barley grains excavated at a cave in the Judean Desert close to the Dead Sea. Comparison to whole exome sequence data from a diversity panel of present-day barley accessions revealed the close affinity of ancient samples to extant landraces from the Southern Levant and Egypt, consistent with a proposed origin of domesticated barley in the Upper Jordan Valley. Our findings suggest that barley landraces grown in present-day Israel in the past six millennia have not experienced a major lineage turnover although there is evidence for gene flow between cultivated and sympatric wild populations. We show the utility of ancient genomes from desiccated archaeobotanical remains in informing research into the origin, early domestication and subsequent migration of crop species.",
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Mascher, M, J. Schuenemann, V, Davidovich, U, Marom, N, Himmelbach, A, Hübner, S, Korol, A, David, M, Reiter, E, Riehl, S, Schreiber, M, Vohr, SH, Green, RE, Dawson, IK, Russell, J, Kilian, B, Muehlbauer, GJ, Waugh, R, Fahima, T, Krause, J, Weiss, E & Stein, N 2016, 'Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley', Nature Genetics, vol. 48, no. 9, pp. 1089-1093. https://doi.org/10.1038/ng.3611

Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley. / Mascher, Martin; J. Schuenemann, Verena; Davidovich, Uri; Marom, Nimrod; Himmelbach, Axel; Hübner, Sariel; Korol, Abraham; David, Michal; Reiter, Ella; Riehl, Simone; Schreiber, Mona; Vohr, Samuel H.; Green, Richard E.; Dawson, Ian K.; Russell, Joanne; Kilian, Benjamin; Muehlbauer, Gary J.; Waugh, Robert; Fahima, Tzion (Lead / Corresponding author); Krause, Johannes (Lead / Corresponding author); Weiss, Ehud (Lead / Corresponding author); Stein, Nils (Lead / Corresponding author).

In: Nature Genetics, Vol. 48, No. 9, 09.2016, p. 1089-1093.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley

AU - Mascher, Martin

AU - J. Schuenemann, Verena

AU - Davidovich, Uri

AU - Marom, Nimrod

AU - Himmelbach, Axel

AU - Hübner, Sariel

AU - Korol, Abraham

AU - David, Michal

AU - Reiter, Ella

AU - Riehl, Simone

AU - Schreiber, Mona

AU - Vohr, Samuel H.

AU - Green, Richard E.

AU - Dawson, Ian K.

AU - Russell, Joanne

AU - Kilian, Benjamin

AU - Muehlbauer, Gary J.

AU - Waugh, Robert

AU - Fahima, Tzion

AU - Krause, Johannes

AU - Weiss, Ehud

AU - Stein, Nils

PY - 2016/9

Y1 - 2016/9

N2 - The cereal grass barley was domesticated about 10,000 years ago in the Fertile Crescent and became a founder crop of Neolithic agriculture. Here, we report genome sequences of five 6,000-year-old barley grains excavated at a cave in the Judean Desert close to the Dead Sea. Comparison to whole exome sequence data from a diversity panel of present-day barley accessions revealed the close affinity of ancient samples to extant landraces from the Southern Levant and Egypt, consistent with a proposed origin of domesticated barley in the Upper Jordan Valley. Our findings suggest that barley landraces grown in present-day Israel in the past six millennia have not experienced a major lineage turnover although there is evidence for gene flow between cultivated and sympatric wild populations. We show the utility of ancient genomes from desiccated archaeobotanical remains in informing research into the origin, early domestication and subsequent migration of crop species.

AB - The cereal grass barley was domesticated about 10,000 years ago in the Fertile Crescent and became a founder crop of Neolithic agriculture. Here, we report genome sequences of five 6,000-year-old barley grains excavated at a cave in the Judean Desert close to the Dead Sea. Comparison to whole exome sequence data from a diversity panel of present-day barley accessions revealed the close affinity of ancient samples to extant landraces from the Southern Levant and Egypt, consistent with a proposed origin of domesticated barley in the Upper Jordan Valley. Our findings suggest that barley landraces grown in present-day Israel in the past six millennia have not experienced a major lineage turnover although there is evidence for gene flow between cultivated and sympatric wild populations. We show the utility of ancient genomes from desiccated archaeobotanical remains in informing research into the origin, early domestication and subsequent migration of crop species.

KW - Genomics

KW - Plant genetics

U2 - 10.1038/ng.3611

DO - 10.1038/ng.3611

M3 - Letter

C2 - 27428749

VL - 48

SP - 1089

EP - 1093

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -

Mascher M, J. Schuenemann V, Davidovich U, Marom N, Himmelbach A, Hübner S et al. Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley. Nature Genetics. 2016 Sep;48(9):1089-1093. https://doi.org/10.1038/ng.3611