Genomic diversity in Fructobacillus spp. isolated from fructose-rich niches

Florencia Mohamed, Luciana G. Ruiz Rodriguez, Azul Zorzoli, Helge Dorfmueller, Raúl R. Raya (Lead / Corresponding author), Fernanda Mozzi (Lead / Corresponding author)

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Abstract

The Fructobacillus genus is a group of obligately fructophilic lactic acid bacteria (FLAB) that requires the use of fructose or another electron acceptor for their growth. In this work, we performed a comparative genomic analysis within the genus Fructobacillus by using 24 available genomes to evaluate genomic and metabolic differences among these organisms. In the genome of these strains, which varies between 1.15- and 1.75-Mbp, nineteen intact prophage regions, and seven complete CRISPR-Cas type II systems were found. Phylogenetic analyses located the studied genomes in two different clades. A pangenome analysis and a functional classification of their genes revealed that genomes of the first clade presented fewer genes involved in the synthesis of amino acids and other nitrogen compounds. Moreover, the presence of genes strictly related to the use of fructose and electron acceptors was variable within the genus, although these variations were not always related to the phylogeny.
Original languageEnglish
Article numbere0281839
Number of pages25
JournalPLoS ONE
Volume18
Issue number2
DOIs
Publication statusPublished - 16 Feb 2023

Keywords

  • Genomics
  • Invertebrate genomics
  • Bacterial genomics
  • Fructoses
  • Phylogenetic analysis
  • Genome analysis
  • Comparative genomics
  • Mannitol

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