Genomic-scale prioritization of drug targets

the TDR Targets database

Fernán Agüero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S Buckner, Robert K Campbell, Santiago Carmona, Ian M Carruthers, A. W. Edith Chan, Feng Chen, Gregory J Crowther, Maria A Doyle, Christiane Hertz-Fowler, Andrew L Hopkins, Gregg McAllister, Solomon Nwaka, John P Overington, Arnab Pain, Gaia V Paolini, Ursula Pieper & 8 others Stuart A Ralph, Aaron Riechers, David S Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C Van Voorhis, Christophe L M J Verlinde

    Research output: Contribution to journalArticle

    207 Citations (Scopus)

    Abstract

    The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
    Original languageEnglish
    Pages (from-to)900-907
    Number of pages8
    JournalNature Reviews Drug Discovery
    Volume7
    Issue number11
    DOIs
    Publication statusPublished - 2008

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    Cite this

    Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., ... Verlinde, C. L. M. J. (2008). Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery, 7(11), 900-907. https://doi.org/10.1038/nrd2684
    Agüero, Fernán ; Al-Lazikani, Bissan ; Aslett, Martin ; Berriman, Matthew ; Buckner, Frederick S ; Campbell, Robert K ; Carmona, Santiago ; Carruthers, Ian M ; Chan, A. W. Edith ; Chen, Feng ; Crowther, Gregory J ; Doyle, Maria A ; Hertz-Fowler, Christiane ; Hopkins, Andrew L ; McAllister, Gregg ; Nwaka, Solomon ; Overington, John P ; Pain, Arnab ; Paolini, Gaia V ; Pieper, Ursula ; Ralph, Stuart A ; Riechers, Aaron ; Roos, David S ; Sali, Andrej ; Shanmugam, Dhanasekaran ; Suzuki, Takashi ; Van Voorhis, Wesley C ; Verlinde, Christophe L M J. / Genomic-scale prioritization of drug targets : the TDR Targets database. In: Nature Reviews Drug Discovery. 2008 ; Vol. 7, No. 11. pp. 900-907.
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    abstract = "The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.",
    author = "Fern{\'a}n Ag{\"u}ero and Bissan Al-Lazikani and Martin Aslett and Matthew Berriman and Buckner, {Frederick S} and Campbell, {Robert K} and Santiago Carmona and Carruthers, {Ian M} and Chan, {A. W. Edith} and Feng Chen and Crowther, {Gregory J} and Doyle, {Maria A} and Christiane Hertz-Fowler and Hopkins, {Andrew L} and Gregg McAllister and Solomon Nwaka and Overington, {John P} and Arnab Pain and Paolini, {Gaia V} and Ursula Pieper and Ralph, {Stuart A} and Aaron Riechers and Roos, {David S} and Andrej Sali and Dhanasekaran Shanmugam and Takashi Suzuki and {Van Voorhis}, {Wesley C} and Verlinde, {Christophe L M J}",
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    Agüero, F, Al-Lazikani, B, Aslett, M, Berriman, M, Buckner, FS, Campbell, RK, Carmona, S, Carruthers, IM, Chan, AWE, Chen, F, Crowther, GJ, Doyle, MA, Hertz-Fowler, C, Hopkins, AL, McAllister, G, Nwaka, S, Overington, JP, Pain, A, Paolini, GV, Pieper, U, Ralph, SA, Riechers, A, Roos, DS, Sali, A, Shanmugam, D, Suzuki, T, Van Voorhis, WC & Verlinde, CLMJ 2008, 'Genomic-scale prioritization of drug targets: the TDR Targets database', Nature Reviews Drug Discovery, vol. 7, no. 11, pp. 900-907. https://doi.org/10.1038/nrd2684

    Genomic-scale prioritization of drug targets : the TDR Targets database. / Agüero, Fernán; Al-Lazikani, Bissan; Aslett, Martin; Berriman, Matthew; Buckner, Frederick S; Campbell, Robert K; Carmona, Santiago; Carruthers, Ian M; Chan, A. W. Edith; Chen, Feng; Crowther, Gregory J; Doyle, Maria A; Hertz-Fowler, Christiane; Hopkins, Andrew L; McAllister, Gregg; Nwaka, Solomon; Overington, John P; Pain, Arnab; Paolini, Gaia V; Pieper, Ursula; Ralph, Stuart A; Riechers, Aaron; Roos, David S; Sali, Andrej; Shanmugam, Dhanasekaran; Suzuki, Takashi; Van Voorhis, Wesley C; Verlinde, Christophe L M J.

    In: Nature Reviews Drug Discovery, Vol. 7, No. 11, 2008, p. 900-907.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Genomic-scale prioritization of drug targets

    T2 - the TDR Targets database

    AU - Agüero, Fernán

    AU - Al-Lazikani, Bissan

    AU - Aslett, Martin

    AU - Berriman, Matthew

    AU - Buckner, Frederick S

    AU - Campbell, Robert K

    AU - Carmona, Santiago

    AU - Carruthers, Ian M

    AU - Chan, A. W. Edith

    AU - Chen, Feng

    AU - Crowther, Gregory J

    AU - Doyle, Maria A

    AU - Hertz-Fowler, Christiane

    AU - Hopkins, Andrew L

    AU - McAllister, Gregg

    AU - Nwaka, Solomon

    AU - Overington, John P

    AU - Pain, Arnab

    AU - Paolini, Gaia V

    AU - Pieper, Ursula

    AU - Ralph, Stuart A

    AU - Riechers, Aaron

    AU - Roos, David S

    AU - Sali, Andrej

    AU - Shanmugam, Dhanasekaran

    AU - Suzuki, Takashi

    AU - Van Voorhis, Wesley C

    AU - Verlinde, Christophe L M J

    PY - 2008

    Y1 - 2008

    N2 - The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

    AB - The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

    U2 - 10.1038/nrd2684

    DO - 10.1038/nrd2684

    M3 - Article

    VL - 7

    SP - 900

    EP - 907

    JO - Nature Reviews Drug Discovery

    JF - Nature Reviews Drug Discovery

    SN - 1474-1776

    IS - 11

    ER -

    Agüero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK et al. Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery. 2008;7(11):900-907. https://doi.org/10.1038/nrd2684