Genomic-scale prioritization of drug targets: the TDR Targets database

Fernán Agüero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S Buckner, Robert K Campbell, Santiago Carmona, Ian M Carruthers, A. W. Edith Chan, Feng Chen, Gregory J Crowther, Maria A Doyle, Christiane Hertz-Fowler, Andrew L Hopkins, Gregg McAllister, Solomon Nwaka, John P Overington, Arnab Pain, Gaia V Paolini, Ursula PieperStuart A Ralph, Aaron Riechers, David S Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C Van Voorhis, Christophe L M J Verlinde

    Research output: Contribution to journalArticle

    217 Citations (Scopus)

    Abstract

    The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
    Original languageEnglish
    Pages (from-to)900-907
    Number of pages8
    JournalNature Reviews Drug Discovery
    Volume7
    Issue number11
    DOIs
    Publication statusPublished - 2008

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  • Cite this

    Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., Carmona, S., Carruthers, I. M., Chan, A. W. E., Chen, F., Crowther, G. J., Doyle, M. A., Hertz-Fowler, C., Hopkins, A. L., McAllister, G., Nwaka, S., Overington, J. P., Pain, A., Paolini, G. V., ... Verlinde, C. L. M. J. (2008). Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery, 7(11), 900-907. https://doi.org/10.1038/nrd2684