Genomic-scale prioritization of drug targets: the TDR Targets database

Fernán Agüero; Bissan Al-Lazikani; Martin Aslett; Matthew Berriman; Frederick S Buckner; Robert K Campbell; Santiago Carmona; Ian M Carruthers; A. W. Edith Chan; Feng Chen; Gregory J Crowther; Maria A Doyle; Christiane Hertz-Fowler; Andrew L Hopkins; Gregg McAllister; Solomon Nwaka; John P Overington; Arnab Pain; Gaia V Paolini; Ursula Pieper; Stuart A Ralph; Aaron Riechers; David S Roos; Andrej Sali; Dhanasekaran Shanmugam; Takashi Suzuki; Wesley C Van Voorhis; Christophe L M J Verlinde

doi:10.1038/nrd2684

Genomic-scale prioritization of drug targets: the TDR Targets database

Fernán Agüero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S Buckner, Robert K Campbell, Santiago Carmona, Ian M Carruthers, A. W. Edith Chan, Feng Chen, Gregory J Crowther, Maria A Doyle, Christiane Hertz-Fowler, Andrew L Hopkins, Gregg McAllister, Solomon Nwaka, John P Overington, Arnab Pain, Gaia V Paolini, Ursula PieperStuart A Ralph, Aaron Riechers, David S Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C Van Voorhis, Christophe L M J Verlinde

Research output: Contribution to journal › Article › peer-review

256 Citations (Scopus)

Abstract

The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

Original language	English
Pages (from-to)	900-907
Number of pages	8
Journal	Nature Reviews Drug Discovery
Volume	7
Issue number	11
DOIs	https://doi.org/10.1038/nrd2684
Publication status	Published - 2008

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Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., Carmona, S., Carruthers, I. M., Chan, A. W. E., Chen, F., Crowther, G. J., Doyle, M. A., Hertz-Fowler, C., Hopkins, A. L., McAllister, G., Nwaka, S., Overington, J. P., Pain, A., Paolini, G. V., ... Verlinde, C. L. M. J. (2008). Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery, 7(11), 900-907. https://doi.org/10.1038/nrd2684

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title = "Genomic-scale prioritization of drug targets: the TDR Targets database",

abstract = "The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.",

author = "Fern{\'a}n Ag{\"u}ero and Bissan Al-Lazikani and Martin Aslett and Matthew Berriman and Buckner, {Frederick S} and Campbell, {Robert K} and Santiago Carmona and Carruthers, {Ian M} and Chan, {A. W. Edith} and Feng Chen and Crowther, {Gregory J} and Doyle, {Maria A} and Christiane Hertz-Fowler and Hopkins, {Andrew L} and Gregg McAllister and Solomon Nwaka and Overington, {John P} and Arnab Pain and Paolini, {Gaia V} and Ursula Pieper and Ralph, {Stuart A} and Aaron Riechers and Roos, {David S} and Andrej Sali and Dhanasekaran Shanmugam and Takashi Suzuki and {Van Voorhis}, {Wesley C} and Verlinde, {Christophe L M J}",

year = "2008",

doi = "10.1038/nrd2684",

language = "English",

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pages = "900--907",

journal = "Nature Reviews Drug Discovery",

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Agüero, F, Al-Lazikani, B, Aslett, M, Berriman, M, Buckner, FS, Campbell, RK, Carmona, S, Carruthers, IM, Chan, AWE, Chen, F, Crowther, GJ, Doyle, MA, Hertz-Fowler, C, Hopkins, AL, McAllister, G, Nwaka, S, Overington, JP, Pain, A, Paolini, GV, Pieper, U, Ralph, SA, Riechers, A, Roos, DS, Sali, A, Shanmugam, D, Suzuki, T, Van Voorhis, WC & Verlinde, CLMJ 2008, 'Genomic-scale prioritization of drug targets: the TDR Targets database', Nature Reviews Drug Discovery, vol. 7, no. 11, pp. 900-907. https://doi.org/10.1038/nrd2684

TY - JOUR

T1 - Genomic-scale prioritization of drug targets

T2 - the TDR Targets database

AU - Agüero, Fernán

AU - Al-Lazikani, Bissan

AU - Aslett, Martin

AU - Berriman, Matthew

AU - Buckner, Frederick S

AU - Campbell, Robert K

AU - Carmona, Santiago

AU - Carruthers, Ian M

AU - Chan, A. W. Edith

AU - Chen, Feng

AU - Crowther, Gregory J

AU - Doyle, Maria A

AU - Hertz-Fowler, Christiane

AU - Hopkins, Andrew L

AU - McAllister, Gregg

AU - Nwaka, Solomon

AU - Overington, John P

AU - Pain, Arnab

AU - Paolini, Gaia V

AU - Pieper, Ursula

AU - Ralph, Stuart A

AU - Riechers, Aaron

AU - Roos, David S

AU - Sali, Andrej

AU - Shanmugam, Dhanasekaran

AU - Suzuki, Takashi

AU - Van Voorhis, Wesley C

AU - Verlinde, Christophe L M J

PY - 2008

Y1 - 2008

N2 - The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

AB - The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

U2 - 10.1038/nrd2684

DO - 10.1038/nrd2684

M3 - Article

C2 - 18927591

SN - 1474-1784

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SP - 900

EP - 907

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

IS - 11

ER -

Genomic-scale prioritization of drug targets: the TDR Targets database

Abstract

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