Gland segmentation in colon histology images using hand-crafted features and convolutional neural networks

Wenqi Li, Siyamalan Manivannan, Shazia Akbar, Jianguo Zhang, Emanuele Trucco, Stephen J. McKenna

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Citations (Scopus)
337 Downloads (Pure)

Abstract

We investigate glandular structure segmentation in colon histology images as a window-based classification problem. We compare and combine methods based on fine-tuned convolutional neural networks (CNN) and hand-crafted features with support vector machines (HC-SVM). On 85 images of H&E-stained tissue, we find that fine-tuned CNN outperforms HC-SVM in gland segmentation measured by pixel-wise Jaccard and Dice indices. For HC-SVM we further observe that training a second-level window classifier on the posterior probabilities – as an output refinement – can substantially improve the segmentation performance. The final performance of HC-SVM with refinement is comparable to that of CNN. Furthermore, we show that by combining and refining the posterior probability out-puts of CNN and HC-SVM together, a further performance boost is obtained.
Original languageEnglish
Title of host publication2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI)
Subtitle of host publicationFrom Nano to Macro, ISBI 2016 - Proceedings
PublisherIEEE
Pages1405-1408
Number of pages4
VolumeJune-2016
ISBN (Electronic)9781479923496
ISBN (Print)9781479923502
DOIs
Publication statusPublished - 16 Jun 2016
Event2016 IEEE 13th International Symposium on Biomedical Imaging - Clarion Congress Hotel, Prague, Czech Republic
Duration: 13 Apr 201616 Apr 2016
http://biomedicalimaging.org/2016/ (Link to Conference website)

Conference

Conference2016 IEEE 13th International Symposium on Biomedical Imaging
Abbreviated titleISBI 2016
CountryCzech Republic
CityPrague
Period13/04/1616/04/16
Internet address

Keywords

  • Glands
  • Image segmentation
  • Support vector machines
  • Feature extraction
  • Dictionaries
  • Training
  • Neural networks

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    Li, W., Manivannan, S., Akbar, S., Zhang, J., Trucco, E., & McKenna, S. J. (2016). Gland segmentation in colon histology images using hand-crafted features and convolutional neural networks. In 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI): From Nano to Macro, ISBI 2016 - Proceedings (Vol. June-2016, pp. 1405-1408). IEEE. https://doi.org/10.1109/ISBI.2016.7493530