Abstract
| Original language | English |
|---|---|
| Article number | 63 |
| Number of pages | 26 |
| Journal | Frontiers in Cellular Neuroscience |
| Volume | 13 |
| DOIs | |
| Publication status | Published - 26 Feb 2019 |
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Keywords
- Astrocytes
- E/I imbalance
- Microglia
- Neurodegeneration
- Synapse loss
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Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration. / Henstridge, Christopher; Tzioras, Makis; Paolicelli, Rosa Chiara.
In: Frontiers in Cellular Neuroscience, Vol. 13, 63, 26.02.2019.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration
AU - Henstridge, Christopher
AU - Tzioras, Makis
AU - Paolicelli, Rosa Chiara
PY - 2019/2/26
Y1 - 2019/2/26
N2 - Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to network dysfunction associated with neurodegeneration. Excitatory and inhibitory activity can be affected by glia-mediated synapse loss, resulting in imbalanced synaptic transmission and subsequent synaptic dysfunction. Here, we review the recent literature on the contribution of glia to excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. A better understanding of the mechanisms underlying pathological synapse loss will be instrumental to design targeted therapeutic interventions, taking in account the emerging roles of microglia and astrocytes in synapse remodeling.
AB - Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to network dysfunction associated with neurodegeneration. Excitatory and inhibitory activity can be affected by glia-mediated synapse loss, resulting in imbalanced synaptic transmission and subsequent synaptic dysfunction. Here, we review the recent literature on the contribution of glia to excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. A better understanding of the mechanisms underlying pathological synapse loss will be instrumental to design targeted therapeutic interventions, taking in account the emerging roles of microglia and astrocytes in synapse remodeling.
KW - Astrocytes
KW - E/I imbalance
KW - Microglia
KW - Neurodegeneration
KW - Synapse loss
UR - http://www.scopus.com/inward/record.url?scp=85064203716&partnerID=8YFLogxK
U2 - 10.3389/fncel.2019.00063
DO - 10.3389/fncel.2019.00063
M3 - Review article
VL - 13
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
SN - 1662-5102
M1 - 63
ER -