Abstract
Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to network dysfunction associated with neurodegeneration. Excitatory and inhibitory activity can be affected by glia-mediated synapse loss, resulting in imbalanced synaptic transmission and subsequent synaptic dysfunction. Here, we review the recent literature on the contribution of glia to excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. A better understanding of the mechanisms underlying pathological synapse loss will be instrumental to design targeted therapeutic interventions, taking in account the emerging roles of microglia and astrocytes in synapse remodeling.
| Original language | English |
|---|---|
| Article number | 63 |
| Number of pages | 26 |
| Journal | Frontiers in Cellular Neuroscience |
| Volume | 13 |
| DOIs | |
| Publication status | Published - 26 Feb 2019 |
Keywords
- Astrocytes
- E/I imbalance
- Microglia
- Neurodegeneration
- Synapse loss
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
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