TY - JOUR
T1 - Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
AU - Magnussen, Christina
AU - Ojeda, Francisco M.
AU - Leong, Darryl P.
AU - Amouyel, Philippe
AU - Aviles-Santa, Larissa
AU - De Bacquer, Dirk
AU - Ballantyne, Christie M.
AU - Bobak, Martin
AU - Brenner, Hermann
AU - De lemos, James
AU - Dobson, Annette
AU - Dörr, Marcus
AU - Donfrancesco, Chiara
AU - Drygas, Wojciech
AU - Dullaart, Robin P.
AU - Engström, Gunnar
AU - Ferrario, Marco M.
AU - Ferrières, Jean
AU - De Gaetano, Giovanni
AU - Goldbourt, Uri
AU - Gonzalez, Clicerio
AU - Grassi, Guido
AU - Hodge, Allison M.
AU - Hveem, Kristian
AU - Lacoviello, Licia
AU - Ikram, M. Kamran
AU - Irazola, Vilma
AU - Jobe, Modou
AU - Jousilahti, Pekka
AU - Kaleebu, Pontiano
AU - Kavousi, Maryam
AU - Kee, Frank
AU - Koenig, Wolfgang
AU - Kontsevaya, Anna
AU - Kuulasmaa, Kari
AU - Lackner, Karl J.
AU - Leistner, David M.
AU - Lind, Lars
AU - Linneberg, Allan
AU - Lorenz, Thiess
AU - Lyngbakken, Magnus nakrem
AU - Malekzadeh, Reza
AU - Malyutina, Sofia
AU - Mathiesen, Ellisiv B.
AU - Melander, Olle
AU - Tunstall-Pedoe, Hugh
N1 - Copyright:
Copyright © 2023 Massachusetts Medical Society.
PY - 2023/10/5
Y1 - 2023/10/5
N2 - Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
AB - Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
KW - Cardiology
KW - Cardiology General
KW - Coronary Disease/Myocardial Infarction
KW - Diabetes
KW - Endocrinology
KW - Hypertension
KW - Lipids
KW - Obesity
KW - Prevention
KW - Public Health
KW - Public Health General
UR - http://www.scopus.com/inward/record.url?scp=85175496095&partnerID=8YFLogxK
U2 - 10.1056/NEJMoa2206916
DO - 10.1056/NEJMoa2206916
M3 - Article
C2 - 37632466
SN - 0028-4793
VL - 389
SP - 1273
EP - 1285
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 14
ER -
