Gluconeogenesis in plants: A key interface between organic acid/amino Acid/Lipid and sugar metabolism

Robert P. Walker (Lead / Corresponding author), Zhi Hui Chen (Lead / Corresponding author), Franco Famiani (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    25 Citations (Scopus)
    90 Downloads (Pure)


    The aims of this article are four‐fold. First, to provide a concise overview of plant gluconeogenesis. Second, to emphasise the widespread occurrence of gluconeogenesis and its utilisation in diverse processes. Third, to stress the importance of the vacuolar storage and release of Krebs cycle acids/nitrogenous compounds; and of the role of gluconeogenesis and malic enzyme in this process. Fourth, to outline the contribution of fine control of enzyme activity to the coordinate‐regulation of gluconeogenesis and malate metabolism; and the importance of cytosolic pH in this.

    Original languageEnglish
    Article number5129
    Number of pages18
    Issue number17
    Publication statusPublished - 24 Aug 2021


    • Gluconeogenesis
    • Malate
    • Malic enzyme
    • Nitrogen metabolism
    • Organic acids
    • Phosphoenolpyruvate carboxykinase
    • Pyruvate orthophosphate dikinase
    • Vacuole

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Chemistry (miscellaneous)
    • Molecular Medicine
    • Pharmaceutical Science
    • Drug Discovery
    • Physical and Theoretical Chemistry
    • Organic Chemistry


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