Projects per year
Abstract
Deficiency of glucose, even under sufficient amino acid supply, turns off translation and promotes catabolic processes to aid cell survival. A recent report by Yoon et al. (2020) shows that glucose is required for the full activity of the leucyl-tRNA synthetase LARS1 and maintains mTORC1 function via LARS1 to enhance translation. Glucose starvation abolishes both effects via phosphorylation of LARS1 by the AMPK-ULK1 signaling pathway. This study supports the idea that glucose starvation inhibits translation at multiple levels.
Original language | English |
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Pages (from-to) | 217-218 |
Number of pages | 2 |
Journal | Cell Metabolism |
Volume | 31 |
Issue number | 2 |
Early online date | 4 Feb 2020 |
DOIs | |
Publication status | Published - 4 Feb 2020 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology
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Dive into the research topics of 'Glucose Starvation Blocks Translation at Multiple Levels'. Together they form a unique fingerprint.Projects
- 1 Finished
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Role of AMPK in Nutrient Sensing and in Cancer (Investigator Award Renewal)
Hardie, G. (Investigator)
1/10/17 → 31/03/24
Project: Research