Glucose Starvation Blocks Translation at Multiple Levels

Chen Song Zhang, D. Grahame Hardie (Lead / Corresponding author), Sheng Cai Lin (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)
165 Downloads (Pure)

Abstract

Deficiency of glucose, even under sufficient amino acid supply, turns off translation and promotes catabolic processes to aid cell survival. A recent report by Yoon et al. (2020) shows that glucose is required for the full activity of the leucyl-tRNA synthetase LARS1 and maintains mTORC1 function via LARS1 to enhance translation. Glucose starvation abolishes both effects via phosphorylation of LARS1 by the AMPK-ULK1 signaling pathway. This study supports the idea that glucose starvation inhibits translation at multiple levels.

Original languageEnglish
Pages (from-to)217-218
Number of pages2
JournalCell Metabolism
Volume31
Issue number2
Early online date4 Feb 2020
DOIs
Publication statusPublished - 4 Feb 2020

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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