Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus

Allan D. Struthers, Michael B. Murphy, Colin T. Dollery

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.
    Copyright © 1985 by American Heart Association
    Original languageEnglish
    Pages (from-to)II95-II101
    Number of pages7
    JournalHypertension
    Volume7
    Issue number6 pt. 2
    DOIs
    Publication statusPublished - 7 Nov 1985

    Fingerprint

    Antihypertensive Agents
    Blood Glucose
    Diabetes Mellitus
    Potassium
    Thiazides
    Sodium Chloride Symporter Inhibitors
    Glucose
    Hypoglycemia
    Hyperglycemia
    Insulin
    Lipids
    Therapeutics
    Serum

    Keywords

    • Hypertension
    • Hyperglycemia
    • Hypokalemia
    • Beta adrenergic receptor antagonists

    Cite this

    Struthers, Allan D. ; Murphy, Michael B. ; Dollery, Colin T. / Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus. In: Hypertension. 1985 ; Vol. 7, No. 6 pt. 2. pp. II95-II101.
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    Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus. / Struthers, Allan D.; Murphy, Michael B.; Dollery, Colin T.

    In: Hypertension, Vol. 7, No. 6 pt. 2, 07.11.1985, p. II95-II101.

    Research output: Contribution to journalArticle

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    AU - Murphy, Michael B.

    AU - Dollery, Colin T.

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    AB - Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.Copyright © 1985 by American Heart Association

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