Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus

Allan D. Struthers; Michael B. Murphy; Colin T. Dollery

doi:10.1161/01.HYP.7.6_Pt_2.II95

Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus

Allan D. Struthers, Michael B. Murphy, Colin T. Dollery

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.
Copyright © 1985 by American Heart Association

Original language	English
Pages (from-to)	II95-II101
Number of pages	7
Journal	Hypertension
Volume	7
Issue number	6 pt. 2
DOIs	https://doi.org/10.1161/01.HYP.7.6_Pt_2.II95
Publication status	Published - 7 Nov 1985

Keywords

Hypertension
Hyperglycemia
Hypokalemia
Beta adrenergic receptor antagonists

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10.1161/01.HYP.7.6_Pt_2.II95

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title = "Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus",

abstract = "Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.Copyright {\textcopyright} 1985 by American Heart Association",

keywords = "Hypertension, Hyperglycemia, Hypokalemia, Beta adrenergic receptor antagonists",

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TY - JOUR

T1 - Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus

AU - Struthers, Allan D.

AU - Murphy, Michael B.

AU - Dollery, Colin T.

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N2 - Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.Copyright © 1985 by American Heart Association

AB - Many antihypertensive drugs have adverse effects on glycemic control when they are used in diabetic patients. This was noted for thiazide diuretics in 1960, and the mechanism of the effects remains uncertain. Indirect evidence suggests that changes in the serum potassium are at least contributory, although the principal mechanism of thiazide-induced hyperglycemia is probably a reduction in the insulin response to glucose. Beta blockers also adversely affect blood sugar control but only by a small margin. The main cause for concern with beta blockers, however, is their effect during hypoglycemia in which nonselective agents delay blood sugar recovery. In diabetic patients, the institution of antihypertensive therapy should be followed by a reassessment to note any changes in sugar, potassium, and lipids, or side effects.Copyright © 1985 by American Heart Association

KW - Hypertension

KW - Hyperglycemia

KW - Hypokalemia

KW - Beta adrenergic receptor antagonists

U2 - 10.1161/01.HYP.7.6_Pt_2.II95

DO - 10.1161/01.HYP.7.6_Pt_2.II95

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SN - 0194-911X

VL - 7

SP - II95-II101

JO - Hypertension

JF - Hypertension

IS - 6 pt. 2

ER -

Glucose tolerance during antihypertensive therapy in patients with diabetes mellitus

Abstract

Keywords

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