Glutamate transporters: a broad review of the most recent archaeal and human structures

Ana Pavić, Alexandra O. M. Holmes, Vincent L. G. Postis, Adrian Goldman (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Glutamate transporters play important roles in bacteria, archaea and eukaryotes. Their function in the mammalian central nervous system is essential for preventing excitotoxicity, and their dysregulation is implicated in many diseases, such as epilepsy and Alzheimer's. Elucidating their transport mechanism would further the understanding of these transporters and promote drug design as they provide compelling targets for understanding the pathophysiology of diseases and may have a direct role in the treatment of conditions involving glutamate excitotoxicity. This review outlines the insights into the transport cycle, uncoupled chloride conductance and modulation, as well as identifying areas that require further investigation.
Original languageEnglish
Pages (from-to)1197-1207
Number of pages11
JournalBiochemical Society Transactions
Volume47
Issue number4
DOIs
Publication statusPublished - 5 Aug 2019

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