Glutamine metabolism and transport in skeletal muscle and heart and their clinical relevance

Michael J. Rennie (Lead / Corresponding author), Aamir Ahmed, Shihab E.O. Khogali, Sylvia Y. Low, Harinder S. Hundal, Peter M. Taylor

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    The glutamine and glutamate transporters in skeletal muscle and heart appear to play a role in control of the steady-state concentration of amino acids in the intracellular space and, in the case of skeletal muscle at least, in the rate of loss of glutamine to the plasma and to other organs and tissues. This article reviews what is currently known about transporter characteristics and mechanisms in skeletal muscle and heart, the alterations in transport activity in pathophysiological conditions and the implications for anabolic processes and cardiac function of altering the availability of glutamine. The possibilities that glutamine pool size is part of an osmotic signaling mechanism to regulate whole body protein metabolism is discussed and evidence is shown from work on cultured muscle cells. The possible uses of glutamine in maintaining cardiac function perioperatively and in promoting glycogen metabolism are discussed.

    Original languageEnglish
    Pages (from-to)1142S-1149S
    Number of pages8
    JournalJournal of Nutrition
    Volume126
    Issue number4 SUPPL.
    DOIs
    Publication statusPublished - 15 Apr 1996

    Keywords

    • glutamate
    • glutamine
    • transport

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