Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase

P C Hayes; A J Hussey; J Keating; I A Bouchier; R Williams; G J Beckett; J D Hayes

doi:10.1016/0009-8981(88)90325-7

Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase

P C Hayes, A J Hussey, J Keating, I A Bouchier, R Williams, G J Beckett, J D Hayes

Research output: Contribution to journal › Article › peer-review

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Abstract

Glutathione S-transferase (GST; EC 2.5.1.18), a sensitive marker of hepatocellular damage, was measured in patients on therapy for histologically proven, autoimmune chronic active hepatitis at various stages of the disease. GST levels were elevated in 65% of serum samples despite immuno-suppressive treatment compared with aspartate transaminase (AST) which was increased in only 23% of samples. In 55% of samples with normal AST concentrations, GST was elevated. No samples demonstrated abnormal transaminase with normal GST levels. It is concluded that continuing hepatocellular damage occurs in patients with autoimmune chronic active hepatitis on immuno-suppressive treatment.

Original language	English
Pages (from-to)	211-6
Number of pages	6
Journal	Clinica Chimica Acta
Volume	172
Issue number	2-3
DOIs	https://doi.org/10.1016/0009-8981(88)90325-7
Publication status	Published - 15 Mar 1988

Keywords

Adolescent
Adult
Aspartate Aminotransferases/blood
Autoimmune Diseases/diagnosis
Clinical Enzyme Tests
Female
Glutathione Transferase/blood
Hepatitis, Chronic/diagnosis
Humans
Male
Middle Aged
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0009-8981(88)90325-7

Cite this

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title = "Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase",

abstract = "Glutathione S-transferase (GST; EC 2.5.1.18), a sensitive marker of hepatocellular damage, was measured in patients on therapy for histologically proven, autoimmune chronic active hepatitis at various stages of the disease. GST levels were elevated in 65% of serum samples despite immuno-suppressive treatment compared with aspartate transaminase (AST) which was increased in only 23% of samples. In 55% of samples with normal AST concentrations, GST was elevated. No samples demonstrated abnormal transaminase with normal GST levels. It is concluded that continuing hepatocellular damage occurs in patients with autoimmune chronic active hepatitis on immuno-suppressive treatment.",

keywords = "Adolescent, Adult, Aspartate Aminotransferases/blood, Autoimmune Diseases/diagnosis, Clinical Enzyme Tests, Female, Glutathione Transferase/blood, Hepatitis, Chronic/diagnosis, Humans, Male, Middle Aged, Prognosis",

author = "Hayes, {P C} and Hussey, {A J} and J Keating and Bouchier, {I A} and R Williams and Beckett, {G J} and Hayes, {J D}",

year = "1988",

month = mar,

day = "15",

doi = "10.1016/0009-8981(88)90325-7",

language = "English",

volume = "172",

pages = "211--6",

journal = "Clinica Chimica Acta",

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number = "2-3",

}

TY - JOUR

T1 - Glutathione S-transferase levels in autoimmune chronic active hepatitis

T2 - a more sensitive index of hepatocellular damage than aspartate transaminase

AU - Hayes, P C

AU - Hussey, A J

AU - Keating, J

AU - Bouchier, I A

AU - Williams, R

AU - Beckett, G J

AU - Hayes, J D

PY - 1988/3/15

Y1 - 1988/3/15

N2 - Glutathione S-transferase (GST; EC 2.5.1.18), a sensitive marker of hepatocellular damage, was measured in patients on therapy for histologically proven, autoimmune chronic active hepatitis at various stages of the disease. GST levels were elevated in 65% of serum samples despite immuno-suppressive treatment compared with aspartate transaminase (AST) which was increased in only 23% of samples. In 55% of samples with normal AST concentrations, GST was elevated. No samples demonstrated abnormal transaminase with normal GST levels. It is concluded that continuing hepatocellular damage occurs in patients with autoimmune chronic active hepatitis on immuno-suppressive treatment.

AB - Glutathione S-transferase (GST; EC 2.5.1.18), a sensitive marker of hepatocellular damage, was measured in patients on therapy for histologically proven, autoimmune chronic active hepatitis at various stages of the disease. GST levels were elevated in 65% of serum samples despite immuno-suppressive treatment compared with aspartate transaminase (AST) which was increased in only 23% of samples. In 55% of samples with normal AST concentrations, GST was elevated. No samples demonstrated abnormal transaminase with normal GST levels. It is concluded that continuing hepatocellular damage occurs in patients with autoimmune chronic active hepatitis on immuno-suppressive treatment.

KW - Adolescent

KW - Adult

KW - Aspartate Aminotransferases/blood

KW - Autoimmune Diseases/diagnosis

KW - Clinical Enzyme Tests

KW - Female

KW - Glutathione Transferase/blood

KW - Hepatitis, Chronic/diagnosis

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

U2 - 10.1016/0009-8981(88)90325-7

DO - 10.1016/0009-8981(88)90325-7

M3 - Article

C2 - 3370835

SN - 0009-8981

VL - 172

SP - 211

EP - 216

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 2-3

ER -

Glutathione S-transferase levels in autoimmune chronic active hepatitis: a more sensitive index of hepatocellular damage than aspartate transaminase

Abstract

Keywords

UN SDGs

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