Glutathione S-transferases in alcoholic liver disease

D J Harrison, L May, P C Hayes, M M Haque, J D Hayes

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    26 Citations (Scopus)

    Abstract

    There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.

    Original languageEnglish
    Pages (from-to)909-12
    Number of pages4
    JournalGut
    Volume31
    Issue number8
    DOIs
    Publication statusPublished - Aug 1990

    Keywords

    • Adult
    • Aged
    • Female
    • Glutathione Transferase/analysis
    • Humans
    • Isoenzymes/analysis
    • Liver Diseases, Alcoholic/enzymology
    • Male
    • Middle Aged

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