Abstract
There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.
Original language | English |
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Pages (from-to) | 909-12 |
Number of pages | 4 |
Journal | Gut |
Volume | 31 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1990 |
Keywords
- Adult
- Aged
- Female
- Glutathione Transferase/analysis
- Humans
- Isoenzymes/analysis
- Liver Diseases, Alcoholic/enzymology
- Male
- Middle Aged