Glycogen synthetase kinase 2 and adenosine 3': 5' cyclic monophosphate independent protein kinase activities in rabbit skeletal muscle

The major phosvitin kinase activity in skeletal muscle is distinct from cyclic adenosine monophosphate dependent protein kinase and phosphorylase kinase. It is closely associated with the protein glycogen complex, but is readily separable from glycogen synthetase itself. The results suggest a promising procedure for the isolation of glycogen synthetase kinase 2 and hence the elucidation of its metabolic role.