Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Pedro Soares, Morgan Gadd, Julianty Frost, Carles Galdeano, Lucy Ellis, Rafiu Epemolu, Sonia Rocha, Kevin Read, Alessio Ciulli (Lead / Corresponding author)