GTPases in antigen receptor signalling

Stefan W Henning (Lead / Corresponding author), Doreen A Cantrell

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Abstract

    Immunological interest in small GTPases has focused for some years almost exclusively on the role of Ras in promoting lymphocyte activation and development. A new concept in this field is that GTPases are linked to multiple biochemical effector signalling pathways and are consequently able to regulate diverse cellular processes. It is also now recognised that GTPases other than Ras regulate lymphocyte biology. Rap1 has been suggested as a negative regulator of lymphocyte responses and Rho GTPases are important components of signalling pathways used by antigen receptors and by costimulatory, cytokine and chemokine receptors to regulate the immune response.

    Original languageEnglish
    Pages (from-to)322-329
    Number of pages8
    JournalCurrent Opinion in Immunology
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - Jun 1998

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