Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

doi:10.1042/BJ20091428

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

60 Citations (Scopus)

Abstract

Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.

Original language	English
Pages (from-to)	53-54
Number of pages	2
Journal	Biochemical Journal
Volume	425
DOIs	https://doi.org/10.1042/BJ20091428
Publication status	Published - 1 Jan 2010

Keywords

cell regulation
chemical biology
chemical inhibitor
protein kinase
signal transduction
KINASE INHIBITORS
IN-VIVO
SPECIFICITY
UPDATE

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10.1042/BJ20091428

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title = "Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation",

abstract = "Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.",

keywords = "cell regulation, chemical biology, chemical inhibitor, protein kinase, signal transduction, KINASE INHIBITORS, IN-VIVO, SPECIFICITY, UPDATE",

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AB - Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.

KW - cell regulation

KW - chemical biology

KW - chemical inhibitor

KW - protein kinase

KW - signal transduction

KW - KINASE INHIBITORS

KW - IN-VIVO

KW - SPECIFICITY

KW - UPDATE

U2 - 10.1042/BJ20091428

DO - 10.1042/BJ20091428

M3 - Review article

SN - 0264-6021

VL - 425

SP - 53

EP - 54

JO - Biochemical Journal

JF - Biochemical Journal

ER -

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Abstract

Keywords

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