Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

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    Abstract

    Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should be accepted for publication.

    Original languageEnglish
    Pages (from-to)53-54
    Number of pages2
    JournalBiochemical Journal
    Volume425
    DOIs
    Publication statusPublished - 1 Jan 2010

    Keywords

    • cell regulation
    • chemical biology
    • chemical inhibitor
    • protein kinase
    • signal transduction
    • KINASE INHIBITORS
    • IN-VIVO
    • SPECIFICITY
    • UPDATE

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