Happy birthday

25 years of DEAD-box proteins

Patrick Linder, Frances Fuller-Pace

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    13 Citations (Scopus)

    Abstract

    RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.

    Original languageEnglish
    Title of host publicationRNA remodeling proteins
    Subtitle of host publicationmethods and protocols
    EditorsMarc Boudvillain
    Place of PublicationNew York
    PublisherSpringer
    Pages17-33
    Number of pages17
    ISBN (Electronic)9781493922147
    ISBN (Print)9781493922130
    DOIs
    Publication statusPublished - 10 Dec 2015

    Publication series

    NameMethods in Molecular Biology
    PublisherSpringer
    Volume1259
    ISSN (Print)1064-3745

    Fingerprint

    RNA
    RNA-Binding Proteins
    Proteins
    DEAD-box RNA Helicases
    Archaea
    Eukaryota
    Adenosine Triphosphate
    Parturition
    Bacteria

    Cite this

    Linder, P., & Fuller-Pace, F. (2015). Happy birthday: 25 years of DEAD-box proteins. In M. Boudvillain (Ed.), RNA remodeling proteins: methods and protocols (pp. 17-33). (Methods in Molecular Biology; Vol. 1259). New York: Springer . https://doi.org/10.1007/978-1-4939-2214-7_2
    Linder, Patrick ; Fuller-Pace, Frances. / Happy birthday : 25 years of DEAD-box proteins. RNA remodeling proteins: methods and protocols. editor / Marc Boudvillain. New York : Springer , 2015. pp. 17-33 (Methods in Molecular Biology).
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    abstract = "RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.",
    author = "Patrick Linder and Frances Fuller-Pace",
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    Linder, P & Fuller-Pace, F 2015, Happy birthday: 25 years of DEAD-box proteins. in M Boudvillain (ed.), RNA remodeling proteins: methods and protocols. Methods in Molecular Biology, vol. 1259, Springer , New York, pp. 17-33. https://doi.org/10.1007/978-1-4939-2214-7_2

    Happy birthday : 25 years of DEAD-box proteins. / Linder, Patrick; Fuller-Pace, Frances.

    RNA remodeling proteins: methods and protocols. ed. / Marc Boudvillain. New York : Springer , 2015. p. 17-33 (Methods in Molecular Biology; Vol. 1259).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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    N2 - RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.

    AB - RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.

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    Linder P, Fuller-Pace F. Happy birthday: 25 years of DEAD-box proteins. In Boudvillain M, editor, RNA remodeling proteins: methods and protocols. New York: Springer . 2015. p. 17-33. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-2214-7_2