Happy birthday: 25 years of DEAD-box proteins

Patrick Linder, Frances Fuller-Pace

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

    28 Citations (Scopus)


    RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.

    Original languageEnglish
    Title of host publicationRNA remodeling proteins
    Subtitle of host publicationmethods and protocols
    EditorsMarc Boudvillain
    Place of PublicationNew York
    Number of pages17
    ISBN (Electronic)9781493922147
    ISBN (Print)9781493922130
    Publication statusPublished - 10 Dec 2015

    Publication series

    NameMethods in Molecular Biology
    ISSN (Print)1064-3745


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