TY - CHAP
T1 - Happy birthday
T2 - 25 years of DEAD-box proteins
AU - Linder, Patrick
AU - Fuller-Pace, Frances
PY - 2015/12/10
Y1 - 2015/12/10
N2 - RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.
AB - RNA helicases of the DEAD-box family are found in all eukaryotes, most bacteria and many archaea. They play important roles in rearranging RNA-RNA and RNA-protein interactions. DEAD-box proteins are ATP-dependent RNA binding proteins and RNA-dependent ATPases. The first helicases of this large family of proteins were described in the 1980s. Since then our perception of these proteins has dramatically changed. From bona fide helicases, they became RNA binding proteins that separate duplex RNAs, in a local manner, by binding and bending the target RNA. In the present review we describe some of the experiments that were important milestones in the life of DEAD-box proteins since their birth 25 years ago.
U2 - 10.1007/978-1-4939-2214-7_2
DO - 10.1007/978-1-4939-2214-7_2
M3 - Chapter (peer-reviewed)
C2 - 25579577
SN - 9781493922130
T3 - Methods in Molecular Biology
SP - 17
EP - 33
BT - RNA remodeling proteins
A2 - Boudvillain, Marc
PB - Springer
CY - New York
ER -