Harvesting the potential of induced biological diversity

Robbie Waugh (Lead / Corresponding author), David J. Leader, Nicola McCallum, David Caldwell

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

For most of the past century, chemical and physical mutagens have been used in plant genetic research to introduce novel genetic variation. In crop improvement, more than 2000 plant varieties that contain induced mutations have been released for cultivation having faced none of the regulatory restrictions imposed on genetically modified material. In plant science, mutational approaches have found extensive use in forward genetics and for enhancer and suppressor screens - particularly in model organisms where positional cloning is easily achieved. However, new approaches that combine mutagenesis with novel and sensitive methods to detect induced DNA sequence variation are establishing a new niche for mutagenesis in the expanding area of (crop) plant functional genomics and providing a bridge that links discovery in models to application in crops.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalTrends in Plant Science
Volume11
Issue number2
Early online date9 Jan 2006
DOIs
Publication statusPublished - 1 Feb 2006

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