Projects per year
Abstract
The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.
Original language | English |
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Pages (from-to) | 907-9 |
Number of pages | 3 |
Journal | Cell Cycle |
Volume | 6 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2007 |
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Dive into the research topics of 'HATs off to capping: a new mechanism for Myc'. Together they form a unique fingerprint.Projects
- 1 Finished
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Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)
3/12/07 → 2/01/14
Project: Research