HATs off to capping: a new mechanism for Myc

Victoria H. Cowling; Michael D. Cole

doi:10.4161/cc.6.8.4123

HATs off to capping: a new mechanism for Myc

Victoria H. Cowling, Michael D. Cole

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.

Original language	English
Pages (from-to)	907-9
Number of pages	3
Journal	Cell Cycle
Volume	6
Issue number	8
DOIs	https://doi.org/10.4161/cc.6.8.4123
Publication status	Published - 2007

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10.4161/cc.6.8.4123

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)
Cowling, V. (Investigator)
3/12/07 → 2/01/14
Project: Research

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title = "HATs off to capping: a new mechanism for Myc",

abstract = "The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.",

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T2 - a new mechanism for Myc

AU - Cowling, Victoria H.

AU - Cole, Michael D.

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AB - The mechanism of transcriptional activation by Myc has been a subject of considerable interest for many years. Recently we reported a novel Myc biochemical function in gene regulation which is distinct from conventional transcriptional activation. Myc can induce global RNA pol II carboxy terminal domain phosphorylation and enhanced mRNA cap methylation on a subset of mRNAs. Remarkably, Myc can induce many of these effects in the complete absence of its DNA binding domain. We further discuss the mechanism of Myc-induced cap methylation, its synergistic relationship with Myc induced transcription, and the role of Myc in cell proliferation.

U2 - 10.4161/cc.6.8.4123

DO - 10.4161/cc.6.8.4123

M3 - Review article

C2 - 17404507

SN - 1551-4005

VL - 6

SP - 907

EP - 909

JO - Cell Cycle

JF - Cell Cycle

IS - 8

ER -

HATs off to capping: a new mechanism for Myc

Abstract

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Projects

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)

Cite this