Projects per year
Abstract
Conceptually, comorbidities such as type 2 diabetes mellitus (T2DM), obesity or chronic kidney disease, all highly prevalent in HF populations, have shifted from being innocent bystanders to drivers of HF. This applies especially to HF with preserved ejection fraction (HFpEF), a phenotype that accounts for more than 50% of HF patients and for which no effective therapy exists thus far.5,6 In particular, the prevalence of T2DM, thereby its combination with HF is rapidly increasing, mainly due to the obesity epidemic.
Cardiovascular (CV) outcomes are addressed by an increasing number of clinical studies in T2DM, mainly as safety endpoints for anti-diabetic agents. Some of those drugs have beneficial CV effects independent of their glucose-lowering action. Consequently, anti-diabetic agents have gained interest for their potential repurposing in HF treatment. In this context, the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) organized a workshop on HF and T2DM, focusing on the pathophysiological and therapeutic aspects of this relationship. Here, we summarize the main points raised during this workshop, providing an overview of current evidence and open issues
Original language | English |
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Article number | ehy596 |
Pages (from-to) | 4243-4254 |
Number of pages | 12 |
Journal | European Heart Journal |
Volume | 39 |
Issue number | 48 |
Early online date | 8 Oct 2018 |
DOIs | |
Publication status | Published - 21 Dec 2018 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Dive into the research topics of 'Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology'. Together they form a unique fingerprint.Projects
- 1 Finished
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Investigation of the Target of Metformin
Prescott, A. (Investigator) & Rena, G. (Investigator)
1/05/13 → 30/04/16
Project: Research
Activities
- 1 Examination
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External Examiner- Aberdeen University
Rena, G. (Examiner)
1 Sept 2018 → …Activity: Examination types › Examination
Press/Media
Profiles
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Rena, Graham
- Diabetes Endocrinology and Reproductive Biology - Professor (Teaching and Research) of CARDIOVASCULAR AND METABOLIC MEDICINE
Person: Academic