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The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT3 receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR. (C) 2011 Elsevier Ltd. All rights reserved.
- 5-HT3 receptor
- Cys-loop ligand-gated ion channels
- Fluorescent ligands
- Radioligand binding
- In vivo imaging
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