High-content imaging zur Identifikation von Replikationsfehlern

Translated title of the contribution: High-content imaging for the identification of replication errors

Karolina Szczesna (Lead / Corresponding author), Viola Denninger (Lead / Corresponding author)

Research output: Contribution to journalComment/debate

Abstract

Dysregulation of DNA-licensing is a hallmark for hereditary diseases, as well as for the development of tumour cells. Here we show how the combination of high-content imaging (HCl) with highly specific antibodies from Proteintech allows deeper insights into the timing of replication licensing following the loading of specific markers onto the DNA. Similar to flow cytometry, HCl can be used to investigate large quantities of cells whilst adding crucial structural information.

Translated title of the contributionHigh-content imaging for the identification of replication errors
Original languageGerman
Pages (from-to)66-68
Number of pages3
JournalBioSpektrum
Volume26
Issue number1
Early online date15 Feb 2020
DOIs
Publication statusPublished - Feb 2020

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