High-content imaging zur Identifikation von Replikationsfehlern

Karolina Szczesna; Viola Denninger

doi:10.1007/s12268-020-1322-5

High-content imaging zur Identifikation von Replikationsfehlern

Translated title of the contribution: High-content imaging for the identification of replication errors

Karolina Szczesna (Lead / Corresponding author), Viola Denninger (Lead / Corresponding author)

Gene Regulation and Expression

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Dysregulation of DNA-licensing is a hallmark for hereditary diseases, as well as for the development of tumour cells. Here we show how the combination of high-content imaging (HCl) with highly specific antibodies from Proteintech allows deeper insights into the timing of replication licensing following the loading of specific markers onto the DNA. Similar to flow cytometry, HCl can be used to investigate large quantities of cells whilst adding crucial structural information.

Translated title of the contribution	High-content imaging for the identification of replication errors
Original language	German
Pages (from-to)	66-68
Number of pages	3
Journal	BioSpektrum
Volume	26
Issue number	1
Early online date	15 Feb 2020
DOIs	https://doi.org/10.1007/s12268-020-1322-5
Publication status	Published - Feb 2020

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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10.1007/s12268-020-1322-5

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title = "High-content imaging zur Identifikation von Replikationsfehlern",

abstract = "Dysregulation of DNA-licensing is a hallmark for hereditary diseases, as well as for the development of tumour cells. Here we show how the combination of high-content imaging (HCl) with highly specific antibodies from Proteintech allows deeper insights into the timing of replication licensing following the loading of specific markers onto the DNA. Similar to flow cytometry, HCl can be used to investigate large quantities of cells whilst adding crucial structural information.",

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AB - Dysregulation of DNA-licensing is a hallmark for hereditary diseases, as well as for the development of tumour cells. Here we show how the combination of high-content imaging (HCl) with highly specific antibodies from Proteintech allows deeper insights into the timing of replication licensing following the loading of specific markers onto the DNA. Similar to flow cytometry, HCl can be used to investigate large quantities of cells whilst adding crucial structural information.

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High-content imaging zur Identifikation von Replikationsfehlern

Abstract

ASJC Scopus subject areas

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