Dysregulation of DNA-licensing is a hallmark for hereditary diseases, as well as for the development of tumour cells. Here we show how the combination of high-content imaging (HCl) with highly specific antibodies from Proteintech allows deeper insights into the timing of replication licensing following the loading of specific markers onto the DNA. Similar to flow cytometry, HCl can be used to investigate large quantities of cells whilst adding crucial structural information.
|Translated title of the contribution||High-content imaging for the identification of replication errors|
|Number of pages||3|
|Early online date||15 Feb 2020|
|Publication status||Published - Feb 2020|
ASJC Scopus subject areas
- Molecular Biology