High-Dose Allopurinol reduces left ventricular mass in patients with ischemic heart disease

Sushma Rekhraj, Stephen J. Gandy, Benjamin R. Szwejkowski, M. Adnan Nadir, Awsan Noman, Graeme Houston, Chim C. Lang, Jacob George, Allan D. Struthers (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    Objectives This study sought to ascertain if high-dose allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD).
    Background LV hypertrophy (LVH) is common in patients with IHD including normotensive patients. Allopurinol, a xanthine oxidase inhibitor, has been shown to reduce LV afterload in IHD and may therefore also regress LVH.
    Methods A randomized, double-blind, placebo-controlled, parallel group study was conducted in 66 patients with IHD and LVH, comparing 600 mg/day allopurinol versus placebo therapy for 9 months. The primary outcome measure was change in LVM, assessed by cardiac magnetic resonance imaging (CMR). Secondary outcome measures were changes in LV volumes by CMR, changes in endothelial function by flow-mediated dilation (FMD), and arterial stiffness by applanation tonometry.
    Results Compared to placebo, allopurinol significantly reduced LVM (allopurinol _5.2 _ 5.8 g vs. placebo _1.3 _ 4.48 g; p _ 0.007) and LVM index (LVMI) (allopurinol _2.2 _ 2.78 g/m2 vs. placebo _0.53 _ 2.5 g/m2; p _ 0.023). The absolute mean difference between groups for change in LVM and LVMI was _3.89 g (95% confidence interval: _1.1 to _6.7) and _1.67 g/m2 (95% confidence interval: _0.23 to _3.1), respectively. Allopurinol also reduced LV endsystolic volume (allopurinol _2.81 _ 7.8 mls vs. placebo _1.3 _ 7.22 mls; p _ 0.047), improved FMD (allopurinol _0.82% _ 1.8% vs. placebo _0.69% _ 2.8%; p _ 0.017) and augmentation index (allopurinol _2.8 _ 5.1% vs. placebo _0.9 _ 7%; p _ 0.02).
    Conclusions High-dose allopurinol regresses LVH, reduces LV end-systolic volume, and improves endothelial function in patients with IHD and LVH. This raises the possibility that allopurinol might reduce future cardiovascular events and mortality in these patients. (Does a Drug Allopurinol Reduce Heart Muscle Mass and Improve Blood Vessel Function in Patients With Normal Blood Pressure and Stable Angina
    Original languageEnglish
    Pages (from-to)926-32
    Number of pages7
    JournalJournal of the American College of Cardiology
    Volume61
    Issue number9
    DOIs
    Publication statusPublished - 5 Mar 2013

    Keywords

    • Allopurinol
    • Ischemic heart disease
    • Oxidative stress
    • Ventricular hypertrophy

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  • Student Theses

    The Effects of Xanthine Oxidase Inhibitors on Left Ventricular Mass and Endothelial Function in Patients with Ischaemic Heart Disease

    Author: Rekhraj, S., 2014

    Supervisor: Struthers, A. (Supervisor) & George, J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Medicine

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