High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

Yuxi Wang; Mingshan Li; Jiahan Ying; Jie Shen; Daolong Dou; Meizhen Yin; Stephen C. Whisson; Paul R. J. Birch; Shuo Yan; Xiaodan Wang

doi:10.1038/s41467-023-41447-8

High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

Yuxi Wang, Mingshan Li, Jiahan Ying, Jie Shen, Daolong Dou, Meizhen Yin, Stephen C. Whisson, Paul R. J. Birch, Shuo Yan (Lead / Corresponding author), Xiaodan Wang (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

75 Downloads (Pure)

Abstract

Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests.

Original language	English
Article number	5622
Number of pages	10
Journal	Nature Communications
Volume	14
DOIs	https://doi.org/10.1038/s41467-023-41447-8
Publication status	Published - 12 Sept 2023

Keywords

Biotic
Gene delivery
Nanoparticles
Pathogens

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

Access to Document

10.1038/s41467-023-41447-8Licence: CC BY

Final Published VersionFinal published version, 2.3 MBLicence: CC BY

Cite this

@article{162632c41b2245ecb5ea7b71169eccf4,

title = "High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant",

abstract = "Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests.",

keywords = "Biotic, Gene delivery, Nanoparticles, Pathogens",

author = "Yuxi Wang and Mingshan Li and Jiahan Ying and Jie Shen and Daolong Dou and Meizhen Yin and Whisson, {Stephen C.} and Birch, {Paul R. J.} and Shuo Yan and Xiaodan Wang",

note = "Funding Information: This work was supported by National Key Research and Development Program of the Ministry of Science and Technology (grant numbers: 2022YFD1401800) to D.D., J.S., X.W. and S.Y.; The National Natural Science Foundation of China (grant numbers: 32372558; 32061130211) to D.D. and X.W.; Biotechnology and Biological Sciences Research Council grant BB/S003096/1, European Research Council (ERC)-Advanced grant PathEVome (787764), and Scottish Government Rural and Environment Science and Analytical Services Division (RESAS) to P.R.J.B. and S.C.W. We thank Associate Prof. Jing Maofeng for reviewing the manuscript and providing suggestions. All authors acknowledge Ministry of Agriculture and Rural Affairs of the People{\textquoteright}s Republic of China for providing official statistics for potato late blight. Copyright: {\textcopyright} 2023, Springer Nature Limited.",

year = "2023",

month = sep,

day = "12",

doi = "10.1038/s41467-023-41447-8",

language = "English",

volume = "14",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

TY - JOUR

T1 - High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

AU - Wang, Yuxi

AU - Li, Mingshan

AU - Ying, Jiahan

AU - Shen, Jie

AU - Dou, Daolong

AU - Yin, Meizhen

AU - Whisson, Stephen C.

AU - Birch, Paul R. J.

AU - Yan, Shuo

AU - Wang, Xiaodan

N1 - Funding Information: This work was supported by National Key Research and Development Program of the Ministry of Science and Technology (grant numbers: 2022YFD1401800) to D.D., J.S., X.W. and S.Y.; The National Natural Science Foundation of China (grant numbers: 32372558; 32061130211) to D.D. and X.W.; Biotechnology and Biological Sciences Research Council grant BB/S003096/1, European Research Council (ERC)-Advanced grant PathEVome (787764), and Scottish Government Rural and Environment Science and Analytical Services Division (RESAS) to P.R.J.B. and S.C.W. We thank Associate Prof. Jing Maofeng for reviewing the manuscript and providing suggestions. All authors acknowledge Ministry of Agriculture and Rural Affairs of the People’s Republic of China for providing official statistics for potato late blight. Copyright: © 2023, Springer Nature Limited.

PY - 2023/9/12

Y1 - 2023/9/12

N2 - Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests.

AB - Potato late blight caused by Phytophthora infestans is a devastating disease worldwide. Unlike other plant pathogens, double-stranded RNA (dsRNA) is poorly taken up by P. infestans, which is a key obstacle in using dsRNA for disease control. Here, a self-assembled multicomponent nano-bioprotectant for potato late blight management is designed based on dsRNA and a plant elicitor. Nanotechnology overcomes the dsRNA delivery bottleneck for P. infestans and extends the RNAi protective window. The protective effect of nano-enabled dsRNA against infection arises from a synergistic mechanism that bolsters the stability of dsRNA and optimizes its effective intracellular delivery. Additionally, the nano-enabled elicitor enhances endocytosis and amplifies the systemic defense response of the plants. Co-delivery of dsRNA and an elicitor provides a protective effect via the two aspects of pathogen inhibition and elevated plant defense mechanisms. The multicomponent nano-bioprotectant exhibits superior control efficacy compared to a commercial synthetic pesticide in field conditions. This work proposes an eco-friendly strategy to manage devastating plant diseases and pests.

KW - Biotic

KW - Gene delivery

KW - Nanoparticles

KW - Pathogens

UR - http://www.scopus.com/inward/record.url?scp=85170703696&partnerID=8YFLogxK

U2 - 10.1038/s41467-023-41447-8

DO - 10.1038/s41467-023-41447-8

M3 - Article

C2 - 37699893

AN - SCOPUS:85170703696

SN - 2041-1723

VL - 14

JO - Nature Communications

JF - Nature Communications

M1 - 5622

ER -

High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

The Roles of Extracellular Vesicle Transport in Late Blight Disease Development (Industrial Partnership Award (IPA))

Cite this

High-efficiency green management of potato late blight by a self-assembled multicomponent nano-bioprotectant

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

The Roles of Extracellular Vesicle Transport in Late Blight Disease Development (Industrial Partnership Award (IPA))

Cite this