High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

Daniela Trani (Lead / Corresponding author), Scott A. Nelson, Bo-Hyun Moon, Jan J. Swedlow, Elizabeth M. Williams, Steven J. Strawn, Paul L. Appleton, Bhaskar Kallakury, Inke Nathke, Albert J. Fornace

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Epidemiological data reveals the gastrointestinal (GI) tract as one of the main sites for low-LET radiation-induced cancers. Importantly, the use of particle therapy is increasing, but cancer risk by high-LET particles is still poorly understood. This gap in our knowledge also remains a major limiting factor in planning long-term space missions. Therefore, assessing risks and identifying predisposing factors for carcinogenesis induced by particle radiation is crucial for both astronauts and cancer survivors. We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than ? rays. However, due to the high number of spontaneous lesions (~30) that develop in Apc(Min/+) animals, this Apc mutant model is not suitable to investigate effects of cumulative doses
    Original languageEnglish
    Pages (from-to)162-71
    Number of pages10
    JournalRadiation Research
    Volume181
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

    Keywords

    • Animals
    • Carcinogenesis
    • Dose-Response Relationship, Radiation
    • Female
    • Gastrointestinal Tract
    • Iron
    • Linear Energy Transfer
    • Male
    • Mice
    • Mice, Inbred C57BL
    • Mitosis
    • Neoplasm Grading
    • Sex Characteristics
    • Tumor Burden

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