High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

Daniela Trani; Scott A. Nelson; Bo-Hyun Moon; Jan J. Swedlow; Elizabeth M. Williams; Steven J. Strawn; Paul L. Appleton; Bhaskar Kallakury; Inke Nathke; Albert J. Fornace

doi:10.1667/RR13502.1

High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

Daniela Trani (Lead / Corresponding author), Scott A. Nelson, Bo-Hyun Moon, Jan J. Swedlow, Elizabeth M. Williams, Steven J. Strawn, Paul L. Appleton, Bhaskar Kallakury, Inke Nathke, Albert J. Fornace

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Epidemiological data reveals the gastrointestinal (GI) tract as one of the main sites for low-LET radiation-induced cancers. Importantly, the use of particle therapy is increasing, but cancer risk by high-LET particles is still poorly understood. This gap in our knowledge also remains a major limiting factor in planning long-term space missions. Therefore, assessing risks and identifying predisposing factors for carcinogenesis induced by particle radiation is crucial for both astronauts and cancer survivors. We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than ? rays. However, due to the high number of spontaneous lesions (~30) that develop in Apc(Min/+) animals, this Apc mutant model is not suitable to investigate effects of cumulative doses

Original language	English
Pages (from-to)	162-71
Number of pages	10
Journal	Radiation Research
Volume	181
Issue number	2
DOIs	https://doi.org/10.1667/RR13502.1
Publication status	Published - Feb 2014

Keywords

Animals
Carcinogenesis
Dose-Response Relationship, Radiation
Female
Gastrointestinal Tract
Iron
Linear Energy Transfer
Male
Mice
Mice, Inbred C57BL
Mitosis
Neoplasm Grading
Sex Characteristics
Tumor Burden

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1667/RR13502.1

http://www.bioone.org/doi/abs/10.1667/RR13502.1

Strategic Award: Wellcome Trust Technology Platform
Blow, J. (Investigator), Lamond, A. (Investigator) & Owen-Hughes, T. (Investigator)
1/01/13 → 30/09/18
Project: Research

Cite this

@article{d4ad99dd04134ee59a53b192c840da5d,

title = "High-energy particle-induced tumorigenesis throughout the gastrointestinal tract",

abstract = "Epidemiological data reveals the gastrointestinal (GI) tract as one of the main sites for low-LET radiation-induced cancers. Importantly, the use of particle therapy is increasing, but cancer risk by high-LET particles is still poorly understood. This gap in our knowledge also remains a major limiting factor in planning long-term space missions. Therefore, assessing risks and identifying predisposing factors for carcinogenesis induced by particle radiation is crucial for both astronauts and cancer survivors. We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than ? rays. However, due to the high number of spontaneous lesions (~30) that develop in Apc(Min/+) animals, this Apc mutant model is not suitable to investigate effects of cumulative doses ",

keywords = "Animals, Carcinogenesis, Dose-Response Relationship, Radiation, Female, Gastrointestinal Tract, Iron, Linear Energy Transfer, Male, Mice, Mice, Inbred C57BL, Mitosis, Neoplasm Grading, Sex Characteristics, Tumor Burden",

author = "Daniela Trani and Nelson, {Scott A.} and Bo-Hyun Moon and Swedlow, {Jan J.} and Williams, {Elizabeth M.} and Strawn, {Steven J.} and Appleton, {Paul L.} and Bhaskar Kallakury and Inke Nathke and Fornace, {Albert J.}",

year = "2014",

month = feb,

doi = "10.1667/RR13502.1",

language = "English",

volume = "181",

pages = "162--71",

journal = "Radiation Research",

issn = "0033-7587",

publisher = "Radiation Research Society",

number = "2",

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TY - JOUR

T1 - High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

AU - Trani, Daniela

AU - Nelson, Scott A.

AU - Moon, Bo-Hyun

AU - Swedlow, Jan J.

AU - Williams, Elizabeth M.

AU - Strawn, Steven J.

AU - Appleton, Paul L.

AU - Kallakury, Bhaskar

AU - Nathke, Inke

AU - Fornace, Albert J.

PY - 2014/2

Y1 - 2014/2

N2 - Epidemiological data reveals the gastrointestinal (GI) tract as one of the main sites for low-LET radiation-induced cancers. Importantly, the use of particle therapy is increasing, but cancer risk by high-LET particles is still poorly understood. This gap in our knowledge also remains a major limiting factor in planning long-term space missions. Therefore, assessing risks and identifying predisposing factors for carcinogenesis induced by particle radiation is crucial for both astronauts and cancer survivors. We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than ? rays. However, due to the high number of spontaneous lesions (~30) that develop in Apc(Min/+) animals, this Apc mutant model is not suitable to investigate effects of cumulative doses

AB - Epidemiological data reveals the gastrointestinal (GI) tract as one of the main sites for low-LET radiation-induced cancers. Importantly, the use of particle therapy is increasing, but cancer risk by high-LET particles is still poorly understood. This gap in our knowledge also remains a major limiting factor in planning long-term space missions. Therefore, assessing risks and identifying predisposing factors for carcinogenesis induced by particle radiation is crucial for both astronauts and cancer survivors. We have previously shown that exposure to relatively high doses of high-energy (56)Fe ions induced higher intestinal tumor frequency and grade in the small intestine of Apc(Min/+) mice than ? rays. However, due to the high number of spontaneous lesions (~30) that develop in Apc(Min/+) animals, this Apc mutant model is not suitable to investigate effects of cumulative doses

KW - Animals

KW - Carcinogenesis

KW - Dose-Response Relationship, Radiation

KW - Female

KW - Gastrointestinal Tract

KW - Iron

KW - Linear Energy Transfer

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mitosis

KW - Neoplasm Grading

KW - Sex Characteristics

KW - Tumor Burden

U2 - 10.1667/RR13502.1

DO - 10.1667/RR13502.1

M3 - Article

C2 - 24512616

SN - 0033-7587

VL - 181

SP - 162

EP - 171

JO - Radiation Research

JF - Radiation Research

IS - 2

ER -

High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

Abstract

Keywords

UN SDGs

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Projects

Strategic Award: Wellcome Trust Technology Platform

Cite this