High-intensity-focused ultrasound and phase-sensitive optical coherence tomography for high resolution surface acoustic wave elastography

Kanheng Zhou, Nhan Le, Zhihong Huang (Lead / Corresponding author), Chunhui Li (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a noninvasive, non-destructive method for accurate characterization of tissue elastic properties. Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW elastography in medical application, a new technique was proposed in this paper, which combines high intensity focused ultrasound (HIFU) as a SAWs impulse inducer and PhS-OCT as a SAWs detector. 2% agar-agar phantom and ex-vivo porcine skin were tested. The data were processed by a new algorithm based on the Fourier analysis. The results show that the proposed method has the capability of quantifying the elastic properties
    of soft tissue mimicking materials. The lateral resolution of the elastogram has been significantly improved and the different layers in heterogeneous material could also been distinguished. Our improved technique of SAW elastography has a large potential to be widely applied in clinical use for skin disease diagnosis and treatment monitoring.
    Original languageEnglish
    Article numbere201700051
    Pages (from-to)1-11
    Number of pages11
    JournalJournal of Biophotonics
    Volume11
    Issue number2
    Early online date12 Jul 2017
    DOIs
    Publication statusPublished - 8 Feb 2018

    Fingerprint

    Elasticity Imaging Techniques
    Optical tomography
    Optical Coherence Tomography
    Surface waves
    tomography
    Ultrasonics
    Acoustic waves
    acoustics
    high resolution
    Skin
    Tissue
    Skin Diseases
    Agar
    High energy lasers
    Elastic Tissue
    Fourier analysis
    Monitoring
    Medical applications
    Fourier Analysis
    impulses

    Keywords

    • high intensity focused ultrasound (HIFU)
    • surface acoustic wave (SAW)
    • Elastography
    • optical coherence tomography (OCT)
    • skin
    • high-intensity-focused ultrasound
    • optical coherence tomography
    • elastography
    • surface acoustic wave

    Cite this

    @article{3e1445ba05ee42db8fcb1ecb9dbe5fe3,
    title = "High-intensity-focused ultrasound and phase-sensitive optical coherence tomography for high resolution surface acoustic wave elastography",
    abstract = "Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a noninvasive, non-destructive method for accurate characterization of tissue elastic properties. Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW elastography in medical application, a new technique was proposed in this paper, which combines high intensity focused ultrasound (HIFU) as a SAWs impulse inducer and PhS-OCT as a SAWs detector. 2{\%} agar-agar phantom and ex-vivo porcine skin were tested. The data were processed by a new algorithm based on the Fourier analysis. The results show that the proposed method has the capability of quantifying the elastic propertiesof soft tissue mimicking materials. The lateral resolution of the elastogram has been significantly improved and the different layers in heterogeneous material could also been distinguished. Our improved technique of SAW elastography has a large potential to be widely applied in clinical use for skin disease diagnosis and treatment monitoring.",
    keywords = "high intensity focused ultrasound (HIFU), surface acoustic wave (SAW), Elastography, optical coherence tomography (OCT), skin, high-intensity-focused ultrasound, optical coherence tomography, elastography, surface acoustic wave",
    author = "Kanheng Zhou and Nhan Le and Zhihong Huang and Chunhui Li",
    note = "Funding: none.",
    year = "2018",
    month = "2",
    day = "8",
    doi = "10.1002/jbio.201700051",
    language = "English",
    volume = "11",
    pages = "1--11",
    journal = "Journal of Biophotonics",
    issn = "1864-063X",
    publisher = "Wiley-VCH",
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    }

    TY - JOUR

    T1 - High-intensity-focused ultrasound and phase-sensitive optical coherence tomography for high resolution surface acoustic wave elastography

    AU - Zhou, Kanheng

    AU - Le, Nhan

    AU - Huang, Zhihong

    AU - Li, Chunhui

    N1 - Funding: none.

    PY - 2018/2/8

    Y1 - 2018/2/8

    N2 - Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a noninvasive, non-destructive method for accurate characterization of tissue elastic properties. Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW elastography in medical application, a new technique was proposed in this paper, which combines high intensity focused ultrasound (HIFU) as a SAWs impulse inducer and PhS-OCT as a SAWs detector. 2% agar-agar phantom and ex-vivo porcine skin were tested. The data were processed by a new algorithm based on the Fourier analysis. The results show that the proposed method has the capability of quantifying the elastic propertiesof soft tissue mimicking materials. The lateral resolution of the elastogram has been significantly improved and the different layers in heterogeneous material could also been distinguished. Our improved technique of SAW elastography has a large potential to be widely applied in clinical use for skin disease diagnosis and treatment monitoring.

    AB - Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a noninvasive, non-destructive method for accurate characterization of tissue elastic properties. Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW elastography in medical application, a new technique was proposed in this paper, which combines high intensity focused ultrasound (HIFU) as a SAWs impulse inducer and PhS-OCT as a SAWs detector. 2% agar-agar phantom and ex-vivo porcine skin were tested. The data were processed by a new algorithm based on the Fourier analysis. The results show that the proposed method has the capability of quantifying the elastic propertiesof soft tissue mimicking materials. The lateral resolution of the elastogram has been significantly improved and the different layers in heterogeneous material could also been distinguished. Our improved technique of SAW elastography has a large potential to be widely applied in clinical use for skin disease diagnosis and treatment monitoring.

    KW - high intensity focused ultrasound (HIFU)

    KW - surface acoustic wave (SAW)

    KW - Elastography

    KW - optical coherence tomography (OCT)

    KW - skin

    KW - high-intensity-focused ultrasound

    KW - optical coherence tomography

    KW - elastography

    KW - surface acoustic wave

    U2 - 10.1002/jbio.201700051

    DO - 10.1002/jbio.201700051

    M3 - Article

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    EP - 11

    JO - Journal of Biophotonics

    JF - Journal of Biophotonics

    SN - 1864-063X

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    ER -