High-intensity-focused ultrasound and phase-sensitive optical coherence tomography for high resolution surface acoustic wave elastography

Kanheng Zhou, Nhan Le, Zhihong Huang (Lead / Corresponding author), Chunhui Li (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Elastography has the ability of quantitatively evaluating the mechanical properties of soft tissue, thus is helpful for diagnosis and treatment monitoring for many diseases, e.g. skin diseases. Surface acoustic waves (SAWs) have been proven to be a noninvasive, non-destructive method for accurate characterization of tissue elastic properties. Current surface acoustic wave elastography using high energy laser pulse or mechanical shaker still have some problems. In order to improve SAW elastography in medical application, a new technique was proposed in this paper, which combines high intensity focused ultrasound (HIFU) as a SAWs impulse inducer and PhS-OCT as a SAWs detector. 2% agar-agar phantom and ex-vivo porcine skin were tested. The data were processed by a new algorithm based on the Fourier analysis. The results show that the proposed method has the capability of quantifying the elastic properties
    of soft tissue mimicking materials. The lateral resolution of the elastogram has been significantly improved and the different layers in heterogeneous material could also been distinguished. Our improved technique of SAW elastography has a large potential to be widely applied in clinical use for skin disease diagnosis and treatment monitoring.
    Original languageEnglish
    Article numbere201700051
    Pages (from-to)1-11
    Number of pages11
    JournalJournal of Biophotonics
    Issue number2
    Early online date12 Jul 2017
    Publication statusPublished - 8 Feb 2018


    • high intensity focused ultrasound (HIFU)
    • surface acoustic wave (SAW)
    • Elastography
    • optical coherence tomography (OCT)
    • skin
    • high-intensity-focused ultrasound
    • optical coherence tomography
    • elastography
    • surface acoustic wave

    ASJC Scopus subject areas

    • General Engineering
    • General Physics and Astronomy
    • General Chemistry
    • General Biochemistry,Genetics and Molecular Biology
    • General Materials Science


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