High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

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  Targeting Tumour Cells with Hyperactive NRF2

  de la Vega, L. (Investigator)

  1/11/18 → 31/10/21

  Project: Research

  • BACH1 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 80%
  • Inflammation 40%
  • Malignant Neoplasm 40%
  • Antioxidant 35%

• HIPK2 as a Novel Determinant of Tumour Progression and Therapeutic Resistance

  de la Vega, L. (Investigator)

  1/02/17 → 1/02/24

  Project: Research

  • BACH1 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 89%
  • Kinase 84%
  • Phosphotransferase 84%
  • Antioxidant 76%

• The Role of the Keap1/Nrf2 Pathway in Tumour Metabolic Adaptation (Joint with University of Cambridge and University College London)

  Dinkova-Kostova, A. (Investigator)

  1/06/15 → 30/04/21

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Transcription Factor Nrf2 43%
  • Kelch-like 40%
  • Associated Proteins 40%
  • Transcription Factor 25%