High-order Connectomic Manifold Learning for Autistic Brain State Identification

Mayssa Soussia, Islem Rekik (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

29 Citations (Scopus)
337 Downloads (Pure)


Previous studies have identified disordered functional (from fMRI) and structural (from diffusion MRI) brain connectivities in Autism Spectrum Disorder (ASD). However, ‘shape connections’ between brain regions were rarely investigated in ASD – e.g., how morphological attributes of a specific brain region (e.g., sulcal depth) change in relation to morphological attributes in other regions. In this paper, we use conventional T1-w MRI to define morphological connectivity networks, each quantifying shape similarity between different cortical regions for a specific cortical attribute at both low-order and high-order levels. For ASD identification, we present a connectomic manifold learning framework, which learns multiple kernels to estimate a similarity measure between ASD and normal controls (NC) connectomic features, to perform dimensionality reduction for clustering ASD and NC subjects. We benchmark our ASD identification method against supervised and unsupervised state-of-the-art methods, while depicting the most discriminative high- and low-order relationships between morphological regions in the left and right hemispheres.
Original languageEnglish
Title of host publicationConnectomics in NeuroImaging
Place of PublicationSwitzerland
Number of pages9
ISBN (Electronic)9783319671598
ISBN (Print)9783319671581
Publication statusPublished - 2017
EventInternational Workshop on Connectomics in Neuroimaging: Held in Conjunction with MICCAI 2017 - Québec City Convention Centre, Centre des congrès de Québec, Québec , Canada
Duration: 14 Sept 2017 → …
Conference number: First International Workshop

Publication series

NameLecture Notes in Computer Science
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


ConferenceInternational Workshop on Connectomics in Neuroimaging
Abbreviated titleCNI 2017
Period14/09/17 → …
Internet address


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