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Abstract
High resolution, microultrasound (μUS) scanning of the gastrointestinal (GI) tract has potential as an important transmural imaging modality to aid in diagnosis. Operating at higher frequencies than conventional clinical ultrasound instruments, μUS is capable of providing scanned images of the GI tract with higher resolution. To investigate the use of μUS for this application, a phantom which is cost effective, within ethical guidelines and, most importantly, similar in histology to the human GI tract is necessary. Therefore, a phantom utilizing porcine small bowel tissue has been developed for custom assembled μUS scanning systems. Two such systems, a stepping scanner and a continuous sweep scanner were utilized to repeatedly scan regions of prepared samples of porcine small bowel tissue. The porcine small bowel tissue phantom was perfused with degassed phosphate buffer saline (dPBS) solution through a cannula inserted in its mesenteric vessel to simulate in vivo conditions and achieve better μUS mucosal characterization. The μUS system scans a transducer across the tissue phantom to acquire RF echo data, which is then processed using MATLAB. A B-scan reconstruction produces 2D images with relative echo strength mapped to a color map of the user's choice. The phantom developed also allows for modifications such as the insertion of fiducial markers to detect tissue change over time and simultaneous perfusion and scanning, providing a platform for more detailed research and investigation into μUS scanning of the GI tract.
Original language | English |
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Title of host publication | Biosensors and Biodetection |
Subtitle of host publication | Methods and Protocols, Volume 2: Electrochemical, Bioelectronic, Piezoelectric, Cellular and Molecular Biosensors |
Editors | Ben Prickril , Avraham Rasooly |
Place of Publication | New York |
Publisher | Springer |
Pages | 541-561 |
Number of pages | 21 |
ISBN (Electronic) | 9781493969111 |
ISBN (Print) | 9781493969104 |
DOIs | |
Publication status | Published - 16 Mar 2017 |
Publication series
Name | Methods in molecular biology |
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Publisher | Springer |
Volume | 1572 |
ISSN (Print) | 1064-3745 |
Keywords
- Microultrasound
- High resolution ultrasound
- Gastrointestinal tract
- Porcine small bowel tissue
- Phantom development
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Dive into the research topics of 'High Resolution Microultrasound (μUS) Investigation of the Gastrointestinal (GI) Tract'. Together they form a unique fingerprint.Projects
- 1 Finished
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Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research