High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography

Shaozhen Song, Nhan Minh Le, Zhihong Huang, Ruikang K. Wang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.

    Original languageEnglish
    Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
    EditorsJames G. Fujimoto, Joseph A. Izatt, Valery V. Tuchin
    Place of PublicationBellington
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628414028
    DOIs
    Publication statusPublished - 2015
    EventSPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX - Moscone Center, San Francisco, United States
    Duration: 9 Feb 201511 Feb 2015
    http://spie.org/x112639.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume9312
    NameProgress in Biomedical Optics and Imaging
    PublisherSPIE
    Number10
    Volume16

    Conference

    ConferenceSPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
    CountryUnited States
    CitySan Francisco
    Period9/02/1511/02/15
    Internet address

    Fingerprint

    Shear waves
    Optical tomography
    Optical Coherence Tomography
    S waves
    tomography
    Elasticity
    high speed
    Imaging techniques
    Elasticity Imaging Techniques
    Lasers
    Tissue
    elastic properties
    Pulsed lasers
    pulsed lasers
    Radio Waves
    Acoustics
    high resolution
    High energy lasers
    requirements
    Equipment and Supplies

    Keywords

    • Acoustic radiation force impulse
    • Elastography
    • Pulsed laser
    • Shear modulus
    • Shear wave imaging

    Cite this

    Song, S., Le, N. M., Huang, Z., & Wang, R. K. (2015). High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography. In J. G. Fujimoto, J. A. Izatt, & V. V. Tuchin (Eds.), Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX [93121G] (Proceedings of SPIE; Vol. 9312), (Progress in Biomedical Optics and Imaging; Vol. 16, No. 10). Bellington: SPIE-International Society for Optical Engineering. https://doi.org/10.1117/12.2080990
    Song, Shaozhen ; Le, Nhan Minh ; Huang, Zhihong ; Wang, Ruikang K. / High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX. editor / James G. Fujimoto ; Joseph A. Izatt ; Valery V. Tuchin. Bellington : SPIE-International Society for Optical Engineering, 2015. (Proceedings of SPIE). (Progress in Biomedical Optics and Imaging; 10).
    @inproceedings{120d01ed69ed423d9f841904e63d9068,
    title = "High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography",
    abstract = "Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.",
    keywords = "Acoustic radiation force impulse, Elastography, Pulsed laser, Shear modulus, Shear wave imaging",
    author = "Shaozhen Song and Le, {Nhan Minh} and Zhihong Huang and Wang, {Ruikang K.}",
    year = "2015",
    doi = "10.1117/12.2080990",
    language = "English",
    isbn = "9781628414028",
    series = "Proceedings of SPIE",
    publisher = "SPIE-International Society for Optical Engineering",
    editor = "Fujimoto, {James G. } and Izatt, {Joseph A. } and Tuchin, {Valery V. }",
    booktitle = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX",

    }

    Song, S, Le, NM, Huang, Z & Wang, RK 2015, High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography. in JG Fujimoto, JA Izatt & VV Tuchin (eds), Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX., 93121G, Proceedings of SPIE, vol. 9312, Progress in Biomedical Optics and Imaging, no. 10, vol. 16, SPIE-International Society for Optical Engineering, Bellington, SPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX, San Francisco, United States, 9/02/15. https://doi.org/10.1117/12.2080990

    High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography. / Song, Shaozhen; Le, Nhan Minh; Huang, Zhihong; Wang, Ruikang K.

    Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX. ed. / James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin. Bellington : SPIE-International Society for Optical Engineering, 2015. 93121G (Proceedings of SPIE; Vol. 9312), (Progress in Biomedical Optics and Imaging; Vol. 16, No. 10).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    TY - GEN

    T1 - High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography

    AU - Song, Shaozhen

    AU - Le, Nhan Minh

    AU - Huang, Zhihong

    AU - Wang, Ruikang K.

    PY - 2015

    Y1 - 2015

    N2 - Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.

    AB - Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.

    KW - Acoustic radiation force impulse

    KW - Elastography

    KW - Pulsed laser

    KW - Shear modulus

    KW - Shear wave imaging

    UR - http://www.scopus.com/inward/record.url?scp=84927726344&partnerID=8YFLogxK

    U2 - 10.1117/12.2080990

    DO - 10.1117/12.2080990

    M3 - Conference contribution

    AN - SCOPUS:84927726344

    SN - 9781628414028

    T3 - Proceedings of SPIE

    BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX

    A2 - Fujimoto, James G.

    A2 - Izatt, Joseph A.

    A2 - Tuchin, Valery V.

    PB - SPIE-International Society for Optical Engineering

    CY - Bellington

    ER -

    Song S, Le NM, Huang Z, Wang RK. High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography. In Fujimoto JG, Izatt JA, Tuchin VV, editors, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX. Bellington: SPIE-International Society for Optical Engineering. 2015. 93121G. (Proceedings of SPIE). (Progress in Biomedical Optics and Imaging; 10). https://doi.org/10.1117/12.2080990