Abstract
Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.
Original language | English |
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Title of host publication | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX |
Editors | James G. Fujimoto, Joseph A. Izatt, Valery V. Tuchin |
Place of Publication | Bellington |
Publisher | SPIE-International Society for Optical Engineering |
ISBN (Print) | 9781628414028 |
DOIs | |
Publication status | Published - 2015 |
Event | SPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX - Moscone Center, San Francisco, United States Duration: 9 Feb 2015 → 11 Feb 2015 http://spie.org/x112639.xml |
Publication series
Name | Proceedings of SPIE |
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Publisher | SPIE |
Volume | 9312 |
Name | Progress in Biomedical Optics and Imaging |
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Publisher | SPIE |
Number | 10 |
Volume | 16 |
Conference
Conference | SPIE Photonics West 2015: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX |
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Country/Territory | United States |
City | San Francisco |
Period | 9/02/15 → 11/02/15 |
Internet address |
Keywords
- Acoustic radiation force impulse
- Elastography
- Pulsed laser
- Shear modulus
- Shear wave imaging
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
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Dive into the research topics of 'High speed imaging of remotely induced shear waves using phasesensitive optical coherence tomography'. Together they form a unique fingerprint.Student theses
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Shear-wave imaging guidance for high-intensity focused ultrasound therapy
Le, M. (Author), Huang, Z. (Supervisor) & Nabi, G. (Supervisor), 2019Student thesis: Doctoral Thesis › Doctor of Philosophy