High-speed imaging of ultrasound-mediated bacterial biofilm disruption

Bing Hui Terence Goh; Michael Conneely; Holger Kneuper; Tracy Palmer; Evert Klaseboer; Boo Cheong Khoo; Paul  Campbell

doi:10.1007/978-3-319-11128-5_133

High-speed imaging of ultrasound-mediated bacterial biofilm disruption

Bing Hui Terence Goh, Michael Conneely, Holger Kneuper, Tracy Palmer, Evert Klaseboer, Boo Cheong Khoo, Paul Campbell

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Bacterial biofilms are common roots of persistent infections. Their structure provides for increased resistance against anti-microbial agents, making them difficult to treat and eradicate. The introduction of ultrasound and microbubble provides the prospect of non-invasive treatment of bacterial biofilms. We adopt the use of a high-speed imaging and optical trapping setup to study the physical mechanisms of ultrasound-mediated microbubble disruption of bacterial biofilms. It was found that the bacterial biofilms could be effectively disrupted due to cavitation collapse of a neighbouring microbubble. However, the efficacy of biofilm disruption depends on several parameters such as stand-off distance and ultrasound parameters.

Original language	English
Title of host publication	6th European Conference of the International Federation for Medical and Biological Engineering
Editors	Igor Lacković, Darko Vasic
Publisher	Springer International Publishing
Pages	533-536
Number of pages	4
ISBN (Electronic)	9783319111285
ISBN (Print)	9783319111278
DOIs	https://doi.org/10.1007/978-3-319-11128-5_133
Publication status	Published - 2015
Event	6th European Conference of the International Federation for Medical and Biological Engineering - Hotel Dubrovnik Palace, Dubrovnik, Croatia Duration: 7 Sept 2014 → 11 Sept 2014 http://www.mbec2014-ifmbe.org/

Publication series

Name	IFMBE proceedings
Publisher	Springer International Publishing
Volume	45
ISSN (Print)	1680-0737

Conference

Conference	6th European Conference of the International Federation for Medical and Biological Engineering
Abbreviated title	MBEC 2014
Country/Territory	Croatia
City	Dubrovnik
Period	7/09/14 → 11/09/14
Internet address	http://www.mbec2014-ifmbe.org/

Keywords

Biofilm
Cavitation
High-speed imaging
Microbubble
Ultrasound

ASJC Scopus subject areas

Biomedical Engineering
Bioengineering

Access to Document

10.1007/978-3-319-11128-5_133

Cite this

Goh, B. H. T., Conneely, M., Kneuper, H., Palmer, T., Klaseboer, E., Khoo, B. C., & Campbell, P. (2015). High-speed imaging of ultrasound-mediated bacterial biofilm disruption. In I. Lacković, & D. Vasic (Eds.), 6th European Conference of the International Federation for Medical and Biological Engineering (pp. 533-536). (IFMBE proceedings; Vol. 45). Springer International Publishing. https://doi.org/10.1007/978-3-319-11128-5_133

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title = "High-speed imaging of ultrasound-mediated bacterial biofilm disruption",

abstract = "Bacterial biofilms are common roots of persistent infections. Their structure provides for increased resistance against anti-microbial agents, making them difficult to treat and eradicate. The introduction of ultrasound and microbubble provides the prospect of non-invasive treatment of bacterial biofilms. We adopt the use of a high-speed imaging and optical trapping setup to study the physical mechanisms of ultrasound-mediated microbubble disruption of bacterial biofilms. It was found that the bacterial biofilms could be effectively disrupted due to cavitation collapse of a neighbouring microbubble. However, the efficacy of biofilm disruption depends on several parameters such as stand-off distance and ultrasound parameters.",

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booktitle = "6th European Conference of the International Federation for Medical and Biological Engineering",

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note = "6th European Conference of the International Federation for Medical and Biological Engineering, MBEC 2014 ; Conference date: 07-09-2014 Through 11-09-2014",

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Goh, BHT, Conneely, M, Kneuper, H, Palmer, T, Klaseboer, E, Khoo, BC & Campbell, P 2015, High-speed imaging of ultrasound-mediated bacterial biofilm disruption. in I Lacković & D Vasic (eds), 6th European Conference of the International Federation for Medical and Biological Engineering. IFMBE proceedings, vol. 45, Springer International Publishing, pp. 533-536, 6th European Conference of the International Federation for Medical and Biological Engineering, Dubrovnik, Croatia, 7/09/14. https://doi.org/10.1007/978-3-319-11128-5_133

High-speed imaging of ultrasound-mediated bacterial biofilm disruption. / Goh, Bing Hui Terence; Conneely, Michael; Kneuper, Holger et al.
6th European Conference of the International Federation for Medical and Biological Engineering. ed. / Igor Lacković; Darko Vasic. Springer International Publishing, 2015. p. 533-536 (IFMBE proceedings; Vol. 45).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - High-speed imaging of ultrasound-mediated bacterial biofilm disruption

AU - Goh, Bing Hui Terence

AU - Conneely, Michael

AU - Kneuper, Holger

AU - Palmer, Tracy

AU - Klaseboer, Evert

AU - Khoo, Boo Cheong

AU - Campbell, Paul

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AB - Bacterial biofilms are common roots of persistent infections. Their structure provides for increased resistance against anti-microbial agents, making them difficult to treat and eradicate. The introduction of ultrasound and microbubble provides the prospect of non-invasive treatment of bacterial biofilms. We adopt the use of a high-speed imaging and optical trapping setup to study the physical mechanisms of ultrasound-mediated microbubble disruption of bacterial biofilms. It was found that the bacterial biofilms could be effectively disrupted due to cavitation collapse of a neighbouring microbubble. However, the efficacy of biofilm disruption depends on several parameters such as stand-off distance and ultrasound parameters.

KW - Biofilm

KW - Cavitation

KW - High-speed imaging

KW - Microbubble

KW - Ultrasound

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Goh BHT, Conneely M, Kneuper H, Palmer T, Klaseboer E, Khoo BC et al. High-speed imaging of ultrasound-mediated bacterial biofilm disruption. In Lacković I, Vasic D, editors, 6th European Conference of the International Federation for Medical and Biological Engineering. Springer International Publishing. 2015. p. 533-536. (IFMBE proceedings). doi: 10.1007/978-3-319-11128-5_133

High-speed imaging of ultrasound-mediated bacterial biofilm disruption

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Keywords

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