High-speed imaging of ultrasound-mediated bacterial biofilm disruption

Bing Hui Terence Goh, Michael Conneely, Holger Kneuper, Tracy Palmer, Evert Klaseboer, Boo Cheong Khoo, Paul Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Bacterial biofilms are common roots of persistent infections. Their structure provides for increased resistance against anti-microbial agents, making them difficult to treat and eradicate. The introduction of ultrasound and microbubble provides the prospect of non-invasive treatment of bacterial biofilms. We adopt the use of a high-speed imaging and optical trapping setup to study the physical mechanisms of ultrasound-mediated microbubble disruption of bacterial biofilms. It was found that the bacterial biofilms could be effectively disrupted due to cavitation collapse of a neighbouring microbubble. However, the efficacy of biofilm disruption depends on several parameters such as stand-off distance and ultrasound parameters.

Original languageEnglish
Title of host publication6th European Conference of the International Federation for Medical and Biological Engineering
EditorsIgor Lacković, Darko Vasic
PublisherSpringer International Publishing
Pages533-536
Number of pages4
ISBN (Electronic)9783319111285
ISBN (Print)9783319111278
DOIs
Publication statusPublished - 2015
Event6th European Conference of the International Federation for Medical and Biological Engineering - Hotel Dubrovnik Palace, Dubrovnik, Croatia
Duration: 7 Sep 201411 Sep 2014
http://www.mbec2014-ifmbe.org/

Publication series

NameIFMBE proceedings
PublisherSpringer International Publishing
Volume45
ISSN (Print)1680-0737

Conference

Conference6th European Conference of the International Federation for Medical and Biological Engineering
Abbreviated titleMBEC 2014
CountryCroatia
CityDubrovnik
Period7/09/1411/09/14
Internet address

Keywords

  • Biofilm
  • Cavitation
  • High-speed imaging
  • Microbubble
  • Ultrasound

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  • Cite this

    Goh, B. H. T., Conneely, M., Kneuper, H., Palmer, T., Klaseboer, E., Khoo, B. C., & Campbell, P. (2015). High-speed imaging of ultrasound-mediated bacterial biofilm disruption. In I. Lacković, & D. Vasic (Eds.), 6th European Conference of the International Federation for Medical and Biological Engineering (pp. 533-536). (IFMBE proceedings; Vol. 45). Springer International Publishing. https://doi.org/10.1007/978-3-319-11128-5_133