High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Nadia Arang, Simone Lubrano, Michele Ceribelli, Damiano C. Rigiracciolo, Robert Saddawi-Konefka, Farhoud Faraji, Sydney I. Ramirez, Daehwan Kim, Frances A. Tosto, Erica Stevenson, Yuan Zhou, Zhiyong Wang, Julius Bogomolovas, Alfredo A. Molinolo, Danielle L. Swaney, Nevan J. Krogan, Jing Yang, Silvia Coma, Jonathan A. Pachter, Andrew E. AplinDario R. Alessi, Craig J. Thomas, J. Silvio Gutkind (Lead / Corresponding author)

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Keyphrases

Biochemistry, Genetics and Molecular Biology

Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science