High yielding microbubble production method

Joe Fiabane, Paul Prentice, Ketan Pancholi

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)
    270 Downloads (Pure)


    Microfluidic approaches to microbubble production are generally disadvantaged by low yield and high susceptibility to (micro)channel blockages. This paper presents an alternative method of producing microbubbles of 2.6 m mean diameter at concentrations in excess of 30 × 106 mL-1. In this method, the nitrogen gas flowing inside the liquid jet is disintegrated into spray of microbubble when air surrounding this coflowing nitrogen gas-liquid jet passes through a 100 m orifice at high velocity. Resulting microbubble foam has the polydispersity index of 16%. Moreover, a ratio of mean microbubble diameter to channel width ratio was found to be less than 0.025, which substantially alleviates the occurrence of blockages during production.

    Original languageEnglish
    Article number3572827
    JournalBioMed Research International
    Publication statusPublished - 2016

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology
    • General Immunology and Microbiology


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