Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

Keyphrases

• Oxidative Stress 100%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• Enones 100%
• UV Radiation 100%
• 6-Thioguanine (6-TG) 100%
• Keap1-Nrf2 Pathway 100%
• UVA Radiation 100%
• Cyano 100%
• Thiopurine Therapy 100%
• Kelch-like ECH-associated Protein 1 (Keap1) 66%
• Genotype 33%
• Highly Effective 33%
• Inducer 33%
• Liver 33%
• Radiation Effects 33%
• Associated Proteins 33%
• Mechanism-based 33%
• Genomic DNA (gDNA) 33%
• Transcription Factor Nrf2 33%
• Inflammation 33%
• Chronic Treatment 33%
• Chemoprotective Effect 33%
• Disease Pathogenesis 33%
• Nanomolar Concentrations 33%
• Cutaneous Squamous Cell Carcinoma (cSCC) 33%
• Cytoprotective Genes 33%
• Protective Effect 33%
• Protein-DNA Complex 33%
• Immunosuppressive Agents 33%
• Anti-inflammatory Agents 33%
• Acetylenic 33%
• Oxidative Inflammation 33%
• Induced Oxidative Stress 33%
• Skin Cells 33%
• Knockout Cells 33%
• Systemic Induction 33%
• 6-thioguanine nucleotides 33%
• Transdermal Delivery 33%
• Skin Patch 33%
• Large-scale Networks 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Transcription Factor Nrf2 100%
• UV Radiation 100%
• Mercaptopurine 100%
• Tioguanine 80%
• Inflammation 40%
• Azathioprine 40%
• Disease 20%
• Bioavailability 20%
• Cytoprotective Agent 20%
• Immunosuppressive Agent 20%
• Antiinflammatory Agent 20%
• Chemoprotective Agent 20%
• Skin Carcinoma 20%
• Genomic DNA 20%
• Transdermal Patch 20%
• Transdermal Delivery 20%