Histone deacetylases

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Deacetylation of histories is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

    Original languageEnglish
    Title of host publicationDrug targets in kinetoplastid parasites
    EditorsHemanta K. Majumder
    Place of PublicationBerlin
    PublisherSpringer
    Pages81-86
    Number of pages6
    ISBN (Electronic)9780387775708
    ISBN (Print)9780387775692
    DOIs
    Publication statusPublished - 2008

    Publication series

    NameAdvances in experimental medicine and biology
    PublisherSpringer
    Volume625
    ISSN (Print)0065-2598

    Keywords

    • ACETYLATION
    • PROTEIN DEACETYLASES
    • INHIBITORS
    • CELL-CYCLE PROGRESSION
    • APICIDIN
    • TRANSCRIPTION
    • CHROMATIN-STRUCTURE
    • EXPRESSION
    • PARASITE
    • TRYPANOSOMA-BRUCEI

    Cite this

    Horn, D. (2008). Histone deacetylases. In H. K. Majumder (Ed.), Drug targets in kinetoplastid parasites (pp. 81-86). (Advances in experimental medicine and biology; Vol. 625). Springer . https://doi.org/10.1007/978-0-387-77570-8