Histone deacetylases

David Horn

doi:10.1007/978-0-387-77570-8

Histone deacetylases

David Horn

Biological Chemistry and Drug Discovery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Deacetylation of histories is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

Original language	English
Title of host publication	Drug targets in kinetoplastid parasites
Editors	Hemanta K. Majumder
Place of Publication	Berlin
Publisher	Springer
Chapter	7
Pages	81-86
Number of pages	6
ISBN (Electronic)	9780387775708
ISBN (Print)	9780387775692
DOIs	https://doi.org/10.1007/978-0-387-77570-8
Publication status	Published - 2008

Publication series

Name	Advances in experimental medicine and biology
Publisher	Springer
Volume	625
ISSN (Print)	0065-2598

Keywords

ACETYLATION
PROTEIN DEACETYLASES
INHIBITORS
CELL-CYCLE PROGRESSION
APICIDIN
TRANSCRIPTION
CHROMATIN-STRUCTURE
EXPRESSION
PARASITE
TRYPANOSOMA-BRUCEI

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-0-387-77570-8

Cite this

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title = "Histone deacetylases",

abstract = "Deacetylation of histories is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.",

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author = "David Horn",

year = "2008",

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language = "English",

isbn = "9780387775692",

series = "Advances in experimental medicine and biology",

publisher = "Springer ",

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T1 - Histone deacetylases

AU - Horn, David

PY - 2008

Y1 - 2008

N2 - Deacetylation of histories is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

AB - Deacetylation of histories is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three kinetoplastid parasites. These enzymes are now being characterised and assessed for chemotherapeutic potential.

KW - ACETYLATION

KW - PROTEIN DEACETYLASES

KW - INHIBITORS

KW - CELL-CYCLE PROGRESSION

KW - APICIDIN

KW - TRANSCRIPTION

KW - CHROMATIN-STRUCTURE

KW - EXPRESSION

KW - PARASITE

KW - TRYPANOSOMA-BRUCEI

U2 - 10.1007/978-0-387-77570-8

DO - 10.1007/978-0-387-77570-8

M3 - Chapter

SN - 9780387775692

T3 - Advances in experimental medicine and biology

SP - 81

EP - 86

BT - Drug targets in kinetoplastid parasites

A2 - Majumder, Hemanta K.

PB - Springer

CY - Berlin

ER -

Histone deacetylases

Abstract

Publication series

Keywords

UN SDGs

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