Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022

TY - JOUR

T1 - Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022

AU - Callaby, Helen

AU - McGuire, Emma

AU - Rajwal, Sanjay

AU - Stahlschmidt, Jens

AU - Hartley, Jane

AU - Brown, Rachel M.

AU - Deheragoda, Maesha

AU - Quaglia, Alberto

AU - Rampling, Tommy

AU - Houlihan, Catherine F.

AU - Claire Gordon, N.

AU - Brown, Colin S.

AU - Simmons, Ruth

AU - Samson, Anda

AU - Mandal, Sema

AU - Grammatikopoulos, Tassos

AU - Demirjian, Alicia

N1 - © 2024 The Authors.

PY - 2024/3

Y1 - 2024/3

N2 - In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A–E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.

AB - In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A–E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak investigation. A working group comprised of infection specialists, hepatologists and histopathologists met virtually to review the cases, presentation, investigations and histopathology. All 20 liver samples had evidence of inflammation without significant interface activity, and submassive confluent pan-lobular or multilobular hepatocellular necrosis. Overall, the predominant histopathological findings were of acute nonspecific hepatitis with submassive hepatic necrosis and central vein perivenulitis and endothelitis. Histopathological findings were a poor indicator of aetiology.

U2 - 10.1002/jpn3.12133

DO - 10.1002/jpn3.12133

M3 - Article

C2 - 38327256

SN - 0277-2116

VL - 78

SP - 534

EP - 538

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

IS - 3

ER -