Historical and current perspective on tobacco use and nicotine addiction

John A. Dani, David J. K. Balfour

    Research output: Contribution to journalReview article

    35 Citations (Scopus)

    Abstract

    Although the addictive influence of tobacco was recognized very early, the modern concepts of nicotine addiction have relied on knowledge of cholinergic neurotransmission and nicotinic acetylcholine receptors (nAChRs). The discovery of the 'receptive substance' by Langley, that would turn out to be nAChRs, and 'Vagusstoff' (acetylcholine) by Loewi, coincided with an exciting time when the concept of chemical synaptic transmission was being formulated. More recently, the application of more powerful techniques and the study of animal models that replicate key features of nicotine dependence have led to important advancements in our understanding of molecular, cellular and systems mechanisms of nicotine addiction. In this review, we present a historical perspective and overview of the research that has led to our present understanding of nicotine addiction.

    Original languageEnglish
    Pages (from-to)383-392
    Number of pages10
    JournalTrends in Neurosciences
    Volume34
    Issue number7
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • FAGERSTROM TOLERANCE QUESTIONNAIRE
    • INTRACRANIAL SELF-STIMULATION
    • MIDBRAIN DOPAMINE NEURONS
    • CUE-INDUCED REINSTATEMENT
    • CENTRAL-NERVOUS-SYSTEM
    • FREELY MOVING RATS
    • ACETYLCHOLINE-RECEPTORS
    • NUCLEUS-ACCUMBENS
    • SYNAPTIC-TRANSMISSION
    • HIPPOCAMPAL-NEURONS

    Cite this