HIV subtypes in Scotland, 2000-2006

D. L. Yirrell, L. Shaw, E. Campbell, S. M. Burns, S. O. Cameron, D. Goldberg

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    6 Citations (Scopus)

    Abstract

    The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.
    Original languageEnglish
    Pages (from-to)1069-1075
    Number of pages7
    JournalEpidemiology and Infection
    Volume136
    Issue number8
    DOIs
    Publication statusPublished - Aug 2008

    Keywords

    • Female
    • Genes, env
    • Genes, gag
    • HIV Infections
    • HIV-1
    • Humans
    • Male
    • Molecular Epidemiology
    • Polymerase Chain Reaction
    • RNA, Viral
    • Risk Factors
    • Scotland

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    Yirrell, D. L., Shaw, L., Campbell, E., Burns, S. M., Cameron, S. O., & Goldberg, D. (2008). HIV subtypes in Scotland, 2000-2006. Epidemiology and Infection, 136(8), 1069-1075. https://doi.org/10.1017/S0950268807009545