HIV subtypes in Scotland, 2000-2006

D. L. Yirrell, L. Shaw, E. Campbell, S. M. Burns, S. O. Cameron, D. Goldberg

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)


    The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.
    Original languageEnglish
    Pages (from-to)1069-1075
    Number of pages7
    JournalEpidemiology and Infection
    Issue number8
    Publication statusPublished - Aug 2008


    • Female
    • Genes, env
    • Genes, gag
    • HIV Infections
    • HIV-1
    • Humans
    • Male
    • Molecular Epidemiology
    • Polymerase Chain Reaction
    • RNA, Viral
    • Risk Factors
    • Scotland


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