HIV subtypes in Scotland, 2000-2006

D. L. Yirrell; L. Shaw; E. Campbell; S. M. Burns; S. O. Cameron; D. Goldberg

doi:10.1017/S0950268807009545

HIV subtypes in Scotland, 2000-2006

D. L. Yirrell
, L. Shaw
, E. Campbell
, S. M. Burns
, S. O. Cameron
, D. Goldberg

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.

Original language	English
Pages (from-to)	1069-1075
Number of pages	7
Journal	Epidemiology and Infection
Volume	136
Issue number	8
DOIs	https://doi.org/10.1017/S0950268807009545
Publication status	Published - Aug 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Female
Genes, env
Genes, gag
HIV Infections
HIV-1
Humans
Male
Molecular Epidemiology
Polymerase Chain Reaction
RNA, Viral
Risk Factors
Scotland

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10.1017/S0950268807009545

Cite this

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title = "HIV subtypes in Scotland, 2000-2006",

abstract = "The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80\% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.",

keywords = "Female, Genes, env, Genes, gag, HIV Infections, HIV-1, Humans, Male, Molecular Epidemiology, Polymerase Chain Reaction, RNA, Viral, Risk Factors, Scotland",

author = "Yirrell, \{D. L.\} and L. Shaw and E. Campbell and Burns, \{S. M.\} and Cameron, \{S. O.\} and D. Goldberg",

year = "2008",

month = aug,

doi = "10.1017/S0950268807009545",

language = "English",

volume = "136",

pages = "1069--1075",

journal = "Epidemiology and Infection",

issn = "0950-2688",

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TY - JOUR

T1 - HIV subtypes in Scotland, 2000-2006

AU - Yirrell, D. L.

AU - Shaw, L.

AU - Campbell, E.

AU - Burns, S. M.

AU - Cameron, S. O.

AU - Goldberg, D.

PY - 2008/8

Y1 - 2008/8

N2 - The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.

AB - The purpose of this study was to document the dynamics of HIV-1 subtypes in Scotland over a 6-year period. Viral RNA from all-new diagnoses was amplified by nested PCR and sequenced in the gag and/or env regions. Subtype was assigned by phylogenetic analysis, and aligned with demographic data including likely route and geographical origin of infection. We present data on 80% of all new diagnoses in Scotland between April 2000 and April 2006. Within the background of an expanding epidemic, subtype B predominates in men who have sex with men and intravenous drug users but there is a small but consistent number of UK-acquired infections in these risk groups caused by non-B subtypes. In heterosexuals, non-B subtypes acquired abroad, especially Africa, are still the largest group but again UK-acquired numbers are rising. The social and clinical significance of the spread of non-B subtypes in different ethnic and risk groups remains to be established.

KW - Female

KW - Genes, env

KW - Genes, gag

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Molecular Epidemiology

KW - Polymerase Chain Reaction

KW - RNA, Viral

KW - Risk Factors

KW - Scotland

U2 - 10.1017/S0950268807009545

DO - 10.1017/S0950268807009545

M3 - Article

C2 - 17922931

SN - 0950-2688

VL - 136

SP - 1069

EP - 1075

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 8

ER -

HIV subtypes in Scotland, 2000-2006

Abstract

UN SDGs

Keywords

Access to Document

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