Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

Peter R. Moult, Jenni Harvey

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    The peripheral functions of hormones such as leptin, insulin and estrogens are well documented. An important and rapidly expanding field is demonstrating that as well as their peripheral actions, these hormones play an important role in modulating synaptic function and structure within the CNS. The hippocampus is a major mediator of spatial learning and memory and is also an area highly susceptible to epileptic seizure. As such, the hippocampus has been extensively studied with particular regard to synaptic plasticity, a process thought to be necessary for learning and memory. Modulators of hippocampal function are therefore of particular interest, not only as potential modulators of learning and memory processes, but also with regard to CNS driven diseases such as epilepsy. Hormones traditionally thought of as only having peripheral roles are now increasingly being shown to have an important role in modulating synaptic plasticity and dendritic morphology. Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena.
    Original languageEnglish
    Pages (from-to)269-275
    Number of pages7
    JournalCell Adhesion and Migration
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 1 Oct 2008

    Fingerprint

    Neuronal Plasticity
    Hormones
    Epilepsy
    Hippocampus
    Learning
    Central Nervous System Diseases
    Leptin
    Estrogens
    Insulin

    Cite this

    @article{d7cb47d62152482fbc98acb90607ff95,
    title = "Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity",
    abstract = "The peripheral functions of hormones such as leptin, insulin and estrogens are well documented. An important and rapidly expanding field is demonstrating that as well as their peripheral actions, these hormones play an important role in modulating synaptic function and structure within the CNS. The hippocampus is a major mediator of spatial learning and memory and is also an area highly susceptible to epileptic seizure. As such, the hippocampus has been extensively studied with particular regard to synaptic plasticity, a process thought to be necessary for learning and memory. Modulators of hippocampal function are therefore of particular interest, not only as potential modulators of learning and memory processes, but also with regard to CNS driven diseases such as epilepsy. Hormones traditionally thought of as only having peripheral roles are now increasingly being shown to have an important role in modulating synaptic plasticity and dendritic morphology. Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena.",
    author = "Moult, {Peter R.} and Jenni Harvey",
    note = "MEDLINE{\circledR} is the source for the citation and abstract of this record.",
    year = "2008",
    month = "10",
    day = "1",
    doi = "10.4161/cam.2.4.6354",
    language = "English",
    volume = "2",
    pages = "269--275",
    journal = "Cell Adhesion and Migration",
    issn = "1933-6918",
    publisher = "Taylor & Francis",
    number = "4",

    }

    Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. / Moult, Peter R.; Harvey, Jenni.

    In: Cell Adhesion and Migration, Vol. 2, No. 4, 01.10.2008, p. 269-275.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

    AU - Moult, Peter R.

    AU - Harvey, Jenni

    N1 - MEDLINE® is the source for the citation and abstract of this record.

    PY - 2008/10/1

    Y1 - 2008/10/1

    N2 - The peripheral functions of hormones such as leptin, insulin and estrogens are well documented. An important and rapidly expanding field is demonstrating that as well as their peripheral actions, these hormones play an important role in modulating synaptic function and structure within the CNS. The hippocampus is a major mediator of spatial learning and memory and is also an area highly susceptible to epileptic seizure. As such, the hippocampus has been extensively studied with particular regard to synaptic plasticity, a process thought to be necessary for learning and memory. Modulators of hippocampal function are therefore of particular interest, not only as potential modulators of learning and memory processes, but also with regard to CNS driven diseases such as epilepsy. Hormones traditionally thought of as only having peripheral roles are now increasingly being shown to have an important role in modulating synaptic plasticity and dendritic morphology. Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena.

    AB - The peripheral functions of hormones such as leptin, insulin and estrogens are well documented. An important and rapidly expanding field is demonstrating that as well as their peripheral actions, these hormones play an important role in modulating synaptic function and structure within the CNS. The hippocampus is a major mediator of spatial learning and memory and is also an area highly susceptible to epileptic seizure. As such, the hippocampus has been extensively studied with particular regard to synaptic plasticity, a process thought to be necessary for learning and memory. Modulators of hippocampal function are therefore of particular interest, not only as potential modulators of learning and memory processes, but also with regard to CNS driven diseases such as epilepsy. Hormones traditionally thought of as only having peripheral roles are now increasingly being shown to have an important role in modulating synaptic plasticity and dendritic morphology. Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena.

    UR - http://www.scopus.com/inward/record.url?scp=65349086691&partnerID=8YFLogxK

    U2 - 10.4161/cam.2.4.6354

    DO - 10.4161/cam.2.4.6354

    M3 - Article

    VL - 2

    SP - 269

    EP - 275

    JO - Cell Adhesion and Migration

    JF - Cell Adhesion and Migration

    SN - 1933-6918

    IS - 4

    ER -