Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity

Peter R. Moult, Jenni Harvey

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    The peripheral functions of hormones such as leptin, insulin and estrogens are well documented. An important and rapidly expanding field is demonstrating that as well as their peripheral actions, these hormones play an important role in modulating synaptic function and structure within the CNS. The hippocampus is a major mediator of spatial learning and memory and is also an area highly susceptible to epileptic seizure. As such, the hippocampus has been extensively studied with particular regard to synaptic plasticity, a process thought to be necessary for learning and memory. Modulators of hippocampal function are therefore of particular interest, not only as potential modulators of learning and memory processes, but also with regard to CNS driven diseases such as epilepsy. Hormones traditionally thought of as only having peripheral roles are now increasingly being shown to have an important role in modulating synaptic plasticity and dendritic morphology. Here we review recent findings demonstrating that a number of hormones are capable of modulating both these phenomena.
    Original languageEnglish
    Pages (from-to)269-275
    Number of pages7
    JournalCell Adhesion and Migration
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 1 Oct 2008

    Fingerprint Dive into the research topics of 'Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity'. Together they form a unique fingerprint.

    Cite this