How can drug discovery for psychiatric disorders be improved?

Yves Agid, György Buzsáki, David M. Diamond, Richard Frackowiak, Jay Giedd, Jean-Antoine Girault, Anthony Grace, Jeremy J. Lambert, Husseini Manji, Helen Mayberg, Maurizio Popoli, Alain Prochiantz, Gal Richter-Levin, Peter Somogyi, Michael Spedding, Per Svenningsson, Daniel Weinberger

    Research output: Contribution to journalReview articlepeer-review

    203 Citations (Scopus)

    Abstract

    Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of disability worldwide, and have a huge societal impact. However, despite the clear need for better therapies, and major advances in the understanding of the molecular basis of these disorders in recent years, efforts to discover and develop new drugs for neuropsychiatric disorders, particularly those that might revolutionize disease treatment, have been relatively unsuccessful. A multidisciplinary approach will be crucial in addressing this problem, and in the first Advances in Neuroscience for Medical Innovation symposium, experts in multiple areas of neuroscience considered key questions in the field, in particular those related to the importance of neuronal plasticity. The discussions were used as a basis to propose steps that can be taken to improve the effectiveness of drug discovery for psychiatric disorders.

    Original languageEnglish
    Pages (from-to)189-201
    Number of pages13
    JournalNature Reviews Drug Discovery
    Volume6
    Issue number3
    DOIs
    Publication statusPublished - Mar 2007

    Keywords

    • Consensus Development Conferences as Topic
    • Drug Design
    • Humans
    • Mental Disorders/drug therapy
    • Models, Biological
    • Practice Guidelines as Topic
    • Signal Transduction/drug effects
    • Surveys and Questionnaires
    • Tranquilizing Agents/pharmacology

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