How is SOS activated? let us count the ways

Greg M Findlay, Tony Pawson

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5- bisphosphate (PIP2) and GTP-bound Ras. These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP2.

    Original languageEnglish
    Pages (from-to)538-540
    Number of pages3
    JournalNature Structural & Molecular Biology
    Issue number6
    Publication statusPublished - 1 Jun 2008


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