How is SOS activated?: let us count the ways

Greg M Findlay; Tony Pawson

doi:10.1038/nsmb0608-538

How is SOS activated? let us count the ways

Greg M Findlay
, Tony Pawson

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5- bisphosphate (PIP₂) and GTP-bound Ras. These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP₂.

Original language	English
Pages (from-to)	538-540
Number of pages	3
Journal	Nature Structural & Molecular Biology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/nsmb0608-538
Publication status	Published - 1 Jun 2008

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abstract = "New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5- bisphosphate (PIP2) and GTP-bound Ras. These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP2.",

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AB - New work shows that activation of the Ras guanine nucleotide exchange factor SOS is dependent upon the membrane density of phosphatidylinositol-4,5- bisphosphate (PIP2) and GTP-bound Ras. These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP2.

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JF - Nature Structural & Molecular Biology

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How is SOS activated? let us count the ways

Abstract

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